北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 细胞生物学系  > 期刊论文
学科主题: 基础医学
题名:
Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis
作者: Yao, Jun-Hua1; Cui, Ming2; Li, Meng-Tao1; Liu, Yi-Nan1; He, Qi-Hua1; Xiao, Jun-Jun1; Bai, Yun1
刊名: PLOS ONE
发表日期: 2014-02-19
DOI: 10.1371/journal.pone.0089148
卷: 9, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: OPERATED CA2+ CHANNELS ; TOLL-LIKE RECEPTORS ; ALPHA-5-BETA-1 INTEGRIN ; TIE2 RECEPTOR ; EXPRESSION ; DEGRANULATION ; PATHWAY ; KINASE ; PHOSPHORYLATION ; MIGRATION
英文摘要:

Since morbidity and mortality rates of anaphylaxis diseases have been increasing year by year, how to prevent and manage these diseases effectively has become an important issue. Mast cells play a central regulatory role in allergic diseases. Angiopoietin1 (Ang-1) exhibits anti-inflammatory properties by inhibiting vascular permeability, leukocyte migration and cytokine production. However, Ang-1′s function in mast cell activation and anaphylaxis diseases is unknown. The results of our study suggest that Ang-1 decreased lipopolysaccharide (LPS)-induced pro-inflammatory cytokines production of mast cells by suppressing I kappa B phosphorylation and NF-kappa B nuclear translocation. Ang-1 also strongly inhibited compound 48/80 induced and FceRI-mediated mast cells degranulation by decreasing intracellular calcium levels in vitro. In vivo lentivirus-mediated delivery of Ang-1 in mice exhibited alleviated leakage in IgE-dependent passive cutaneous anaphylaxis (PCA). Furthermore, exogenous Ang-1 intervention treatment prevented mice from compound 48/80-induced mesentery mast cell degranulation, attenuated increases in pro-inflammatory cytokines, relieved lung injury, and improved survival in anaphylaxis shock. The results of our study reveal, for the first time, the important role of Ang-1 in the activation of mast cells, and identify a therapeutic effect of Ang-1 on anaphylaxis diseases.

语种: 英语
所属项目编号: 31070948 ; 81070260 ; 81272432 ; 7102099
项目资助者: National Natural Sciences Foundation of China ; Beijing National Sciences Foundation
WOS记录号: WOS:000331711900095
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67891
Appears in Collections:基础医学院_细胞生物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol, Beijing 100871, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Yao, Jun-Hua,Cui, Ming,Li, Meng-Tao,et al. Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis[J]. PLOS ONE,2014,9(2).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yao, Jun-Hua]'s Articles
[Cui, Ming]'s Articles
[Li, Meng-Tao]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yao, Jun-Hua]‘s Articles
[Cui, Ming]‘s Articles
[Li, Meng-Tao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace