IR@PKUHSC  > 北京大学基础医学院  > 细胞生物学系
学科主题基础医学
Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis
Yao, Jun-Hua1; Cui, Ming2; Li, Meng-Tao1; Liu, Yi-Nan1; He, Qi-Hua1; Xiao, Jun-Jun1; Bai, Yun1
刊名PLOS ONE
2014-02-19
DOI10.1371/journal.pone.0089148
9期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]OPERATED CA2+ CHANNELS ; TOLL-LIKE RECEPTORS ; ALPHA-5-BETA-1 INTEGRIN ; TIE2 RECEPTOR ; EXPRESSION ; DEGRANULATION ; PATHWAY ; KINASE ; PHOSPHORYLATION ; MIGRATION
英文摘要

Since morbidity and mortality rates of anaphylaxis diseases have been increasing year by year, how to prevent and manage these diseases effectively has become an important issue. Mast cells play a central regulatory role in allergic diseases. Angiopoietin1 (Ang-1) exhibits anti-inflammatory properties by inhibiting vascular permeability, leukocyte migration and cytokine production. However, Ang-1′s function in mast cell activation and anaphylaxis diseases is unknown. The results of our study suggest that Ang-1 decreased lipopolysaccharide (LPS)-induced pro-inflammatory cytokines production of mast cells by suppressing I kappa B phosphorylation and NF-kappa B nuclear translocation. Ang-1 also strongly inhibited compound 48/80 induced and FceRI-mediated mast cells degranulation by decreasing intracellular calcium levels in vitro. In vivo lentivirus-mediated delivery of Ang-1 in mice exhibited alleviated leakage in IgE-dependent passive cutaneous anaphylaxis (PCA). Furthermore, exogenous Ang-1 intervention treatment prevented mice from compound 48/80-induced mesentery mast cell degranulation, attenuated increases in pro-inflammatory cytokines, relieved lung injury, and improved survival in anaphylaxis shock. The results of our study reveal, for the first time, the important role of Ang-1 in the activation of mast cells, and identify a therapeutic effect of Ang-1 on anaphylaxis diseases.

语种英语
WOS记录号WOS:000331711900095
项目编号31070948 ; 81070260 ; 81272432 ; 7102099
资助机构National Natural Sciences Foundation of China ; Beijing National Sciences Foundation
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67891
专题北京大学基础医学院_细胞生物学系
北京大学医学部管理机构_医学部
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol, Beijing 100871, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yao, Jun-Hua,Cui, Ming,Li, Meng-Tao,et al. Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis[J]. PLOS ONE,2014,9(2).
APA Yao, Jun-Hua.,Cui, Ming.,Li, Meng-Tao.,Liu, Yi-Nan.,He, Qi-Hua.,...&Bai, Yun.(2014).Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis.PLOS ONE,9(2).
MLA Yao, Jun-Hua,et al."Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis".PLOS ONE 9.2(2014).
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