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Changes of renal function and structure in rats exposed to cold
Shi, Hongmei; He, Lihua; Wang, Sheng; Zhang, Ying; Ye, Kangping
关键词angiotensin type I receptor cold-induced hypertension kidney nitric oxide nitric oxide synthase oxidative stress rat
刊名JOURNAL OF THERMAL BIOLOGY
2007-10-01
DOI10.1016/j.jtherbio.2007.08.002
32期:7-8页:421-427
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology ; Zoology
研究领域[WOS]Life Sciences & Biomedicine - Other Topics ; Zoology
关键词[WOS]ANGIOTENSIN-II RECEPTORS ; NITRIC-OXIDE SYNTHASE ; INDUCED HYPERTENSION ; BLOOD-PRESSURE ; OXIDATIVE STRESS ; IN-VIVO ; ELEVATION ; SUPEROXIDE ; ARTERIES ; PATHWAY
英文摘要

The kidney appears to play a crucial role in both initiating and maintaining the high blood pressure in cold-induced hypertension (CIH). The aim of the present study was to evaluate the changes of renal function and structure in rats exposed to cold for 2, 4 and 6 weeks. Systolic blood pressure increased significantly after 2 weeks of cold exposure and was maintained throughout the whole experiment. Upregulation of angiotensin type I receptor (AT(1)R) expression was seen in the vascular zone and distal tubule after 4 and 6 weeks of cold exposure. This was accompanied by an increase in malondialdehyde (MDA) levels and decreases in superoxide dismutase (SOD), nitric oxide synthase (NOS) activities and nitric oxide (NO) content in kidney. Structural changes were also observed in glomeruli, tubules and arteries in cold-treated rats. These results suggest that upregulation of kidney AT(1)R plays a critical role in the development of CIH, and its interaction with oxidative stress, NO and NOS may be involved in changes of renal function and structure. (c) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000251117400008
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67893
专题北京大学公共卫生学院
作者单位Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100083, Peoples R China
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GB/T 7714
Shi, Hongmei,He, Lihua,Wang, Sheng,et al. Changes of renal function and structure in rats exposed to cold[J]. JOURNAL OF THERMAL BIOLOGY,2007,32(7-8):421-427.
APA Shi, Hongmei,He, Lihua,Wang, Sheng,Zhang, Ying,&Ye, Kangping.(2007).Changes of renal function and structure in rats exposed to cold.JOURNAL OF THERMAL BIOLOGY,32(7-8),421-427.
MLA Shi, Hongmei,et al."Changes of renal function and structure in rats exposed to cold".JOURNAL OF THERMAL BIOLOGY 32.7-8(2007):421-427.
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