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学科主题: 公共卫生
题名:
Changes of renal function and structure in rats exposed to cold
作者: Shi, Hongmei; He, Lihua; Wang, Sheng; Zhang, Ying; Ye, Kangping
关键词: angiotensin type I receptor ; cold-induced hypertension ; kidney ; nitric oxide ; nitric oxide synthase ; oxidative stress ; rat
刊名: JOURNAL OF THERMAL BIOLOGY
发表日期: 2007-10-01
DOI: 10.1016/j.jtherbio.2007.08.002
卷: 32, 期:7-8, 页:421-427
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology ; Zoology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics ; Zoology
关键词[WOS]: ANGIOTENSIN-II RECEPTORS ; NITRIC-OXIDE SYNTHASE ; INDUCED HYPERTENSION ; BLOOD-PRESSURE ; OXIDATIVE STRESS ; IN-VIVO ; ELEVATION ; SUPEROXIDE ; ARTERIES ; PATHWAY
英文摘要:

The kidney appears to play a crucial role in both initiating and maintaining the high blood pressure in cold-induced hypertension (CIH). The aim of the present study was to evaluate the changes of renal function and structure in rats exposed to cold for 2, 4 and 6 weeks. Systolic blood pressure increased significantly after 2 weeks of cold exposure and was maintained throughout the whole experiment. Upregulation of angiotensin type I receptor (AT(1)R) expression was seen in the vascular zone and distal tubule after 4 and 6 weeks of cold exposure. This was accompanied by an increase in malondialdehyde (MDA) levels and decreases in superoxide dismutase (SOD), nitric oxide synthase (NOS) activities and nitric oxide (NO) content in kidney. Structural changes were also observed in glomeruli, tubules and arteries in cold-treated rats. These results suggest that upregulation of kidney AT(1)R plays a critical role in the development of CIH, and its interaction with oxidative stress, NO and NOS may be involved in changes of renal function and structure. (c) 2007 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000251117400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67893
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Shi, Hongmei,He, Lihua,Wang, Sheng,et al. Changes of renal function and structure in rats exposed to cold[J]. JOURNAL OF THERMAL BIOLOGY,2007,32(7-8):421-427.
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