IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Tubulocystic carcinoma of the kidney - Clinicopathologic and molecular characterization
Yang, Ximing J.1,2; Zhou, Ming3; Hes, Ondrej4; Shen, Steven5,6; Li, Rongshan7; Lopez, Jose8; Shah, Rajal B.9; Yang, Yu10; Chuang, Shang-Tian2; Lin, Fan11; Tretiakova, Maria M.12; Kort, Eric J.13; Teh, Bin Tean13
关键词kidney cancer microarray collecting duct cystic
刊名AMERICAN JOURNAL OF SURGICAL PATHOLOGY
2008-02-01
32期:2页:177-187
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology ; Surgery
研究领域[WOS]Pathology ; Surgery
关键词[WOS]RENAL-CELL CARCINOMA ; MEDULLARY CARCINOMA ; EXPRESSION ; CLASSIFICATION ; NEOPLASMS ; FEATURES ; ORIGIN ; TUMORS ; ALPHA ; P504S
英文摘要

The nature of tubulocystic carcinoma, a rare renal tumor composed of tubular and cystic structures, is poorly understood. It has been suggested that it may represent a low-grade collecting duct carcinoma of the kidney despite the lack of sufficient molecular and pathologic evidence. The aim of this study was to examine the clinical and pathologic features of 13 cases of tubulocystic carcinoma of the kidney. Furthermore, using gene expression microarray analysis, we defined the molecular signature of this tumor by comparing it with other renal tumors in our previously established molecular profile database. Histologically, all 13 tumors were composed of closely packed tubules and cysts of varying sizes separated by fibrovascular septa. The epithelial lining cells of the tubules and cysts in this tumor were characterized by abundant eosinophilic cytoplasm with prominent nucleoli often showing a hobnail appearance. Clinically, one of the 13 cases showed metastasis to the pelvic lymph nodes. Five of the 13 cases coexisted with papillary renal cell carcinoma (RCC) (n = 3) or papillary adenoma (n = 2). In addition, the molecular profile of tubulocystic carcinoma was similar but not identical to those of papillary RCC by clustering analysis. Through comparative genomic microarray analysis, tubulocystic carcinoma showed gains of chromosome 17, but not chromosome 7, whereas most papillary RCCs showed chromosomal gains in both 7 and 17 (trisomies). Therefore, based on its unique pathologic features and molecular signature as well as its biologic behavior to develop metastasis either by itself or in association with papillary RCC, tubulocystic carcinoma of the kidney should be recognized as a distinct subtype of RCC and be distinguished from other malignant and benign cystic lesions of the kidney.

语种英语
WOS记录号WOS:000252759900001
Citation statistics
Cited Times:97[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67901
Collection北京大学基础医学院_病理学系
作者单位1.Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
2.Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA
3.Northwestern Univ, Dept Pathol, Chicago, IL 60611 USA
4.Cleveland Clin, Dept Anat Pathol, Cleveland, OH 44106 USA
5.Charles Univ Hosp, Dept Pathol, Plzen, Czech Republic
6.Methodist Hosp, Dept Pathol, Houston, TX 77030 USA
7.Weill Cornell Med Coll, Houston, TX USA
8.Med Coll Wisconsin, Dept Pathol, Milwaukee, WI 53226 USA
9.Geisinger Med Ctr, Dept Lab Med, Danville, PA 17822 USA
10.Univ Basque Country, Dept Atom Pathol, Hosp Cruces, Bizkaia, Spain
11.Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
12.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
13.Van Andel Res Inst, Canc Genet Lab, Grand Rapids, MI USA
Recommended Citation
GB/T 7714
Yang, Ximing J.,Zhou, Ming,Hes, Ondrej,et al. Tubulocystic carcinoma of the kidney - Clinicopathologic and molecular characterization[J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY,2008,32(2):177-187.
APA Yang, Ximing J..,Zhou, Ming.,Hes, Ondrej.,Shen, Steven.,Li, Rongshan.,...&Teh, Bin Tean.(2008).Tubulocystic carcinoma of the kidney - Clinicopathologic and molecular characterization.AMERICAN JOURNAL OF SURGICAL PATHOLOGY,32(2),177-187.
MLA Yang, Ximing J.,et al."Tubulocystic carcinoma of the kidney - Clinicopathologic and molecular characterization".AMERICAN JOURNAL OF SURGICAL PATHOLOGY 32.2(2008):177-187.
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