IR@PKUHSC  > 北京大学第一临床医学院  > 儿科
学科主题临床医学
Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents
Zhang, Qingyou; Jin, Hongfang; Qi, Jianguang; Yan, Hui; Du, Junbao
关键词Brain natriuretic peptide Pediatric Syncope
刊名ACTA PAEDIATRICA
2013-05-01
DOI10.1111/apa.12182
102期:5页:e210-e214
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics
研究领域[WOS]Pediatrics
关键词[WOS]EMERGENCY-DEPARTMENT ; RISK STRATIFICATION ; PEDIATRIC-PATIENTS ; HEART-FAILURE ; MANAGEMENT ; BNP
英文摘要

Aim This study was designed to evaluate the diagnostic value of B-type natriuretic peptide (BNP) in syncope in children and adolescents. Methods Serum BNP concentration was measured by electrochemiluminescence assay in 62 consecutive children and adolescents hospitalized for syncope. Results Of the 62 children and adolescents hospitalized for syncope, 39 had noncardiac syncope, of whom 37 (59.7%) had autonomic-mediated reflex syncope and two (3.2%) had syncope of unknown cause. Twenty-three patients (37.1%) had cardiac syncope: 11 of these had cardiac arrhythmias and 12 had structural cardiac/cardiopulmonary disease. Patients with cardiac syncope had significantly higher serum BNP than those with non-cardiac syncope (958.78 +/- 2443.41pg/mL vs 31.05 +/- 22.64pg/mL, p<0.05). Logistic multivariate regression analysis revealed that urinary incontinence during syncopal episodes, ECG abnormalities and increased serum BNP levels were independent predictors of cardiac syncope. At a cut-off value of 40.65pg/mL, serum BNP was associated with significant risk of a cardiac cause of syncope, with sensitivity of 73.9% and specificity of 70.0% for distinguishing cardiac syncope from noncardiac syncope. Conclusion Serum BNP was helpful in differentiating cardiac syncope from noncardiac syncope in children and adolescents.

语种英语
WOS记录号WOS:000317361400007
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67906
Collection北京大学第一临床医学院_儿科
作者单位Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Qingyou,Jin, Hongfang,Qi, Jianguang,et al. Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents[J]. ACTA PAEDIATRICA,2013,102(5):e210-e214.
APA Zhang, Qingyou,Jin, Hongfang,Qi, Jianguang,Yan, Hui,&Du, Junbao.(2013).Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents.ACTA PAEDIATRICA,102(5),e210-e214.
MLA Zhang, Qingyou,et al."Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents".ACTA PAEDIATRICA 102.5(2013):e210-e214.
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