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学科主题: 临床医学
题名:
Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents
作者: Zhang, Qingyou; Jin, Hongfang; Qi, Jianguang; Yan, Hui; Du, Junbao
关键词: Brain natriuretic peptide ; Pediatric ; Syncope
刊名: ACTA PAEDIATRICA
发表日期: 2013-05-01
DOI: 10.1111/apa.12182
卷: 102, 期:5, 页:e210-e214
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pediatrics
研究领域[WOS]: Pediatrics
关键词[WOS]: EMERGENCY-DEPARTMENT ; RISK STRATIFICATION ; PEDIATRIC-PATIENTS ; HEART-FAILURE ; MANAGEMENT ; BNP
英文摘要:

Aim This study was designed to evaluate the diagnostic value of B-type natriuretic peptide (BNP) in syncope in children and adolescents. Methods Serum BNP concentration was measured by electrochemiluminescence assay in 62 consecutive children and adolescents hospitalized for syncope. Results Of the 62 children and adolescents hospitalized for syncope, 39 had noncardiac syncope, of whom 37 (59.7%) had autonomic-mediated reflex syncope and two (3.2%) had syncope of unknown cause. Twenty-three patients (37.1%) had cardiac syncope: 11 of these had cardiac arrhythmias and 12 had structural cardiac/cardiopulmonary disease. Patients with cardiac syncope had significantly higher serum BNP than those with non-cardiac syncope (958.78 +/- 2443.41pg/mL vs 31.05 +/- 22.64pg/mL, p<0.05). Logistic multivariate regression analysis revealed that urinary incontinence during syncopal episodes, ECG abnormalities and increased serum BNP levels were independent predictors of cardiac syncope. At a cut-off value of 40.65pg/mL, serum BNP was associated with significant risk of a cardiac cause of syncope, with sensitivity of 73.9% and specificity of 70.0% for distinguishing cardiac syncope from noncardiac syncope. Conclusion Serum BNP was helpful in differentiating cardiac syncope from noncardiac syncope in children and adolescents.

语种: 英语
WOS记录号: WOS:000317361400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67906
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Qingyou,Jin, Hongfang,Qi, Jianguang,et al. Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents[J]. ACTA PAEDIATRICA,2013,102(5):e210-e214.
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