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学科主题: 临床医学
题名:
The Significance of Metastasectomy in Patients with Metastatic Renal Cell Carcinoma in the Era of Targeted Therapy
作者: Yu, Xiaoteng1; Wang, Bing2; Li, Xuesong1; Lin, Gang3; Zhang, Cuijian1; Yang, Yang1; Fang, Dong1; Song, Yi1; He, Zhisong1; Zhou, Liqun1
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2015
DOI: 10.1155/2015/176373
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: PROGNOSTIC-FACTORS ; SURVIVAL ; CANCER ; NEPHRECTOMY ; RESECTION ; TUMORS ; TRIAL
英文摘要:

Objective. To investigate the efficacy of surgery in the treatment of metastatic renal cell carcinoma (mRCC) and to identify prognostic factors. Methods. A single center retrospective study of 96 patients with mRCC from December 2004 to August 2013. Results. The median follow-up time was 45 months. Thirty-one (32.3%) of the patients received complete resection of metastatic sites, 11 (11.5%) of the patients underwent incomplete resection of metastatic sites, and 54 (56.3%) of the patients received no surgery. In the univariate Kaplan-Meier analysis, the median overall survival times of the three groups were 52 months, 16 months, and 22 months, respectively (p < 0.001). The difference in the overall survival time was statistically significant between complete resection and no surgery groups (HR = 0.43, p = 0.009), while there was no significant difference between the incomplete metastasectomy and no surgery groups (HR = 1.80, p = 0.102). According to the multivariate Cox regression analysis, complete metastasectomy (HR = 0.49, p = 0.033), T stage > 3 (HR = 1.88, p = 0.015), disease free interval <12 months (HR = 2.34, p = 0.003), and multiorgan involvement (HR = 2.00, p = 0.011) were significant prognostic factors. Conclusion. In the era of targeted therapy, complete metastasectomy can improve overall survival. Complete metastasectomy, T stage > 3, disease free interval <12 months, and multiorgan involvement are independent prognostic factors.

语种: 英语
WOS记录号: WOS:000363563300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67909
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Natl Urol Canc Ctr, Hosp 1, Inst Urol,Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Dept Orthoped, Hosp 1, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Dept Thorac Surg, Beijing 100034, Peoples R China

Recommended Citation:
Yu, Xiaoteng,Wang, Bing,Li, Xuesong,et al. The Significance of Metastasectomy in Patients with Metastatic Renal Cell Carcinoma in the Era of Targeted Therapy[J]. BIOMED RESEARCH INTERNATIONAL,2015.
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