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学科主题: 临床医学
题名:
High pericardial and peri-aortic adipose tissue burden in pre-diabetic and diabetic subjects
作者: Yang, Fei-Shih1; Yun, Chun-Ho1,2; Wu, Tung-Hsin2; Hsieh, Ya-Ching3; Bezerra, Hiram G.4; Liu, Chuan-Chuan5,6,7; Wu, Yih-Jer8,9,10,11; Kuo, Jen-Yuan8,9,10; Hung, Chung-Lieh5,8,9,10; Hou, Charles Jia-Yin8,9,10; Yeh, Hung-I8,9,10; Lee, Jason Jeun-Shenn2; Bulwer, Bernard E.12,13; Cury, Ricardo C.14
关键词: Pre-diabetes ; Diabetes mellitus ; MDCT ; Pericardial adipose tissue ; Peri-aortic adipose tissue ; Insulin resistance
刊名: BMC CARDIOVASCULAR DISORDERS
发表日期: 2013-11-11
DOI: 10.1186/1471-2261-13-98
卷: 13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: VISCERAL ABDOMINAL FAT ; CORONARY ATHEROSCLEROSIS ; CARDIOVASCULAR-DISEASE ; SICK FAT ; RISK ; ASSOCIATION ; ADIPOSOPATHY ; CONTRIBUTE ; MELLITUS ; GLUCOSE
英文摘要:

Background: Central obesity in relation to insulin resistance is strongly linked to the development of type 2 diabetes. However, data regarding the association between pericardial and peri-aortic adiposity, a potential estimate of visceral adipose tissue burden, and pre-diabetes status remains unclear. The aim of this study was to examine whether the degree of pericardial and thoracic peri-aortic adipose tissue, when quantified by multi-detector computed tomography (MDCT), differs significantly in a normal, pre-diabetic, and overtly diabetic population.

Methods: We studied 562 consecutive subjects including 357 healthy, 155 pre-diabetic, and 50 diabetic patients selected from participants who underwent annual health surveys in Taiwan. Pre-diabetes status was defined by impaired fasting glucose or impaired glucose intolerance according to American Diabetes Association guidelines. Pericardial (PCF) and thoracic peri-aortic (TAT) adipose tissue burden was assessed using a non-contrast 16-slice multi-detector computed tomography (MDCT) dataset with off-line measurement (Aquarius 3D Workstation, TeraRecon, SanMateo, CA, USA). Body fat composition, serum high-sensitivity C-reactive protein (hs-CRP) level and insulin resistance (HOMA-IR) were also assessed.

Results: Patients with diabetes and pre-diabetes had greater volume of PCF (89 +/- 24.6, 85.3 +/- 28.7 & 67.6 +/- 26.7 ml, p < 0.001) as well as larger TAT (9.6 +/- 3.1 ml vs 8.8 +/- 4.2 & 6.6 +/- 3.5 ml, respectively, p < 0.001) when compared to the normal group, although there were no significant differences in adiposity between the diabetic and pre-diabetic groups. For those without established diabetes in our study, increasing TAT burden, but not PCF, appear to correlate with insulin resistance (HOMA-IR) and hs-CRP in the multivariable models.

Conclusions: Pre-diabetic and diabetic subjects, compared to normoglycemia, were associated with significantly higher pericardial and peri-aortic adipose tissue burden. In addition, visceral fat accumulation adjacent to the thoracic aorta seemed to exert a significant impact on insulin resistance and systemic inflammation.

语种: 英语
所属项目编号: 101-2314-B-195-020
项目资助者: Mackay Memorial Hospital ; NSC
WOS记录号: WOS:000328424300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67910
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Mackay Med Nursing & Management Coll, Taipei, Taiwan
2.Massachusetts Coll Pharm & Hlth Sci, Boston, MA USA
3.Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA
4.Natl Yang Ming Univ, Inst Tradit Med, Taipei 112, Taiwan
5.Mackay Mem Hosp, Dept Radiol, Taipei, Taiwan
6.Mackay Mem Hosp, Hlth Evaluat Ctr, Taipei, Taiwan
7.Yuanpei Univ Sci & Technol, Dept Med Technol, Hsinchu, Taiwan
8.Mackay Med Coll, Dept Med, Taipei, Taiwan
9.Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei 112, Taiwan
10.Peking Univ, Hosp 1, Dept Anesthesia, Beijing 100871, Peoples R China
11.Univ Hosp Cleveland, Case Med Ctr, Cardiovasc Dept, Cleveland, OH 44106 USA
12.Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Hlth Care Org Adm, Taipei 10764, Taiwan
13.Mackay Mem Hosp, Div Cardiol, Dept Internal Med, Taipei, Taiwan
14.Baptist Cardiac & Vasc Inst, Cardiovasc MRI & CT Program, Dept Radiol, Miami, FL USA

Recommended Citation:
Yang, Fei-Shih,Yun, Chun-Ho,Wu, Tung-Hsin,et al. High pericardial and peri-aortic adipose tissue burden in pre-diabetic and diabetic subjects[J]. BMC CARDIOVASCULAR DISORDERS,2013,13.
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