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Association study of NRXN3 polymorphisms with schizophrenia and risperidone-induced bodyweight gain in Chinese Han population
Hu, Xiaofeng1,2; Zhang, Jishui3; Jin, Chao4; Mi, Weifeng1,2; Wang, Fang1,2; Ma, Wenbin4; Ma, Cuicui4; Yang, Yongfeng5,6; Li, Wenqiang5,6; Zhang, Hongxing5,6; Du, Bo7; Li, Keqing7; Liu, Chenxing1,2; Wang, Lifang1,2; Lu, Tianlan1,2; Zhang, Hongyan1,2; Lv, Luxian5,6; Zhang, Dai1,2; Yue, Weihua1,2
关键词Antipsychotics Neurexin-3 (NRXN3) Schizophrenia
刊名PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
2013-06-03
DOI10.1016/j.pnpbp.2012.12.007
43页:197-202
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
资助者National Natural Science Foundation of China ; Beijing Metropolis ; National Natural Science Foundation of China ; Beijing Metropolis
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]WHOLE-GENOME ASSOCIATION ; INDUCED WEIGHT-GAIN ; NICOTINE DEPENDENCE ; CELL-ADHESION ; SPECTRUM DISORDER ; WIDE ASSOCIATION ; NEUROLIGIN ; NEUREXINS ; GENETICS ; SYNAPSE
英文摘要

Recent researches have implicated that mutations in the neurexin-3 (NRXN3) gene on chromosome 14q243-q31.1 might play a role in addiction, autism, and obesity. In order to explore the association of NRXN3 polymorphisms with schizophrenia, we examined seven single nucleotide polymorphisms (SNPs) in NRXN3 spanning 1.33 Mb of this gene, in a Chinese Han sample of 1214 schizophrenic patients and 1517 healthy control subjects. Our results showed that three SNPs were associated with schizophrenia (rs7157669: A>C, p=0.006; rs724373: C>T, p=0.014; rs7154021: C>T, p=0.018). After being corrected for multiple tests, the association of rs7157669 remained significant but those for two others were modest. According to the linkage disequilibrium pattern, the 7 SNPs may construct 3 haplotype blocks. Several haplotypes were significantly associated with schizophrenia, constructed by rs11624704-rs7157669-rs724373 (MC, p=0.003; ACT, p = 0.007, both remained significant after permutation tests), rs7154021-rs7142344 (TT, p = 0.024; CT, p=0.012), respectively. Among the patients, 326 ones at first onset have received 6-week monotherapy of risperidone. Further analyses showed that two SNPs were associated with percentage of bodyweight gain following a 6-week therapy of risperidone (rs11624704: p=0.03; rs7154021: p=0.008) and rs7154021 remained significant after permutation test. Our findings suggested that NRXN3 might represent a major susceptibility gene for schizophrenia and have a role in bodyweight gain related to therapy of risperidone in Chinese Han population. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
所属项目编号81071087 ; 81071088 ; 2009A03
资助者National Natural Science Foundation of China ; Beijing Metropolis ; National Natural Science Foundation of China ; Beijing Metropolis
WOS记录号WOS:000317878700025
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67912
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Jinzhou Kangning Hosp, Jinzhou 121013, Liaoning, Peoples R China
3.Hebei Mental Hlth Ctr, Baoding 071000, Hebei, Peoples R China
4.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
5.Capital Univ Med Sci, Being Childrens Hosp, Beijing 100045, Peoples R China
6.Xinxiang Med Univ, Affiliated Hosp 2, Dept Psychiat, Xinxiang 453002, Henan, Peoples R China
7.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang 453002, Henan, Peoples R China
推荐引用方式
GB/T 7714
Hu, Xiaofeng,Zhang, Jishui,Jin, Chao,et al. Association study of NRXN3 polymorphisms with schizophrenia and risperidone-induced bodyweight gain in Chinese Han population[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2013,43:197-202.
APA Hu, Xiaofeng.,Zhang, Jishui.,Jin, Chao.,Mi, Weifeng.,Wang, Fang.,...&Yue, Weihua.(2013).Association study of NRXN3 polymorphisms with schizophrenia and risperidone-induced bodyweight gain in Chinese Han population.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,43,197-202.
MLA Hu, Xiaofeng,et al."Association study of NRXN3 polymorphisms with schizophrenia and risperidone-induced bodyweight gain in Chinese Han population".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 43(2013):197-202.
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