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学科主题: 精神卫生
题名:
Association study of NRXN3 polymorphisms with schizophrenia and risperidone-induced bodyweight gain in Chinese Han population
作者: Hu, Xiaofeng1,2; Zhang, Jishui3; Jin, Chao4; Mi, Weifeng1,2; Wang, Fang1,2; Ma, Wenbin4; Ma, Cuicui4; Yang, Yongfeng5,6; Li, Wenqiang5,6; Zhang, Hongxing5,6; Du, Bo7; Li, Keqing7; Liu, Chenxing1,2; Wang, Lifang1,2; Lu, Tianlan1,2; Zhang, Hongyan1,2; Lv, Luxian5,6; Zhang, Dai1,2; Yue, Weihua1,2
关键词: Antipsychotics ; Neurexin-3 (NRXN3) ; Schizophrenia
刊名: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
发表日期: 2013-06-03
DOI: 10.1016/j.pnpbp.2012.12.007
卷: 43, 页:197-202
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: WHOLE-GENOME ASSOCIATION ; INDUCED WEIGHT-GAIN ; NICOTINE DEPENDENCE ; CELL-ADHESION ; SPECTRUM DISORDER ; WIDE ASSOCIATION ; NEUROLIGIN ; NEUREXINS ; GENETICS ; SYNAPSE
英文摘要:

Recent researches have implicated that mutations in the neurexin-3 (NRXN3) gene on chromosome 14q243-q31.1 might play a role in addiction, autism, and obesity. In order to explore the association of NRXN3 polymorphisms with schizophrenia, we examined seven single nucleotide polymorphisms (SNPs) in NRXN3 spanning 1.33 Mb of this gene, in a Chinese Han sample of 1214 schizophrenic patients and 1517 healthy control subjects. Our results showed that three SNPs were associated with schizophrenia (rs7157669: A>C, p=0.006; rs724373: C>T, p=0.014; rs7154021: C>T, p=0.018). After being corrected for multiple tests, the association of rs7157669 remained significant but those for two others were modest. According to the linkage disequilibrium pattern, the 7 SNPs may construct 3 haplotype blocks. Several haplotypes were significantly associated with schizophrenia, constructed by rs11624704-rs7157669-rs724373 (MC, p=0.003; ACT, p = 0.007, both remained significant after permutation tests), rs7154021-rs7142344 (TT, p = 0.024; CT, p=0.012), respectively. Among the patients, 326 ones at first onset have received 6-week monotherapy of risperidone. Further analyses showed that two SNPs were associated with percentage of bodyweight gain following a 6-week therapy of risperidone (rs11624704: p=0.03; rs7154021: p=0.008) and rs7154021 remained significant after permutation test. Our findings suggested that NRXN3 might represent a major susceptibility gene for schizophrenia and have a role in bodyweight gain related to therapy of risperidone in Chinese Han population. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 81071087 ; 81071088 ; 2009A03
项目资助者: National Natural Science Foundation of China ; Beijing Metropolis
WOS记录号: WOS:000317878700025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67912
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Jinzhou Kangning Hosp, Jinzhou 121013, Liaoning, Peoples R China
3.Hebei Mental Hlth Ctr, Baoding 071000, Hebei, Peoples R China
4.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
5.Capital Univ Med Sci, Being Childrens Hosp, Beijing 100045, Peoples R China
6.Xinxiang Med Univ, Affiliated Hosp 2, Dept Psychiat, Xinxiang 453002, Henan, Peoples R China
7.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang 453002, Henan, Peoples R China

Recommended Citation:
Hu, Xiaofeng,Zhang, Jishui,Jin, Chao,et al. Association study of NRXN3 polymorphisms with schizophrenia and risperidone-induced bodyweight gain in Chinese Han population[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2013,43:197-202.
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