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学科主题: 临床医学
题名:
Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer′s disease in Chinese
作者: Zhao, FG; Wang, YH; Yang, JF; Ma, QL; Tang, Z; Dong, XM; Chan, P
刊名: NEUROSCIENCE LETTERS
发表日期: 2005-11-04
DOI: 10.1016/j.neulet.2005.06.020
卷: 388, 期:1, 页:17-20
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: APOLIPOPROTEIN-E POLYMORPHISM ; POPULATION ; BRAIN ; CONNECTION ; GENERATION ; ALLELE
英文摘要:

There is a compelling body of evidence indicating an association between cholesterol and Alzheimer′s disease (AD). Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1), an endoplasmic-reticulum-resident enzyme that catalyses the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids, modulates the generation of beta amyloid peptide (A beta). A single nucleotide polymorphism rs1044925 in the sterol O-acyltransferase 1 (SOAT1), the gene encoding ACAT1, has been reported to be association with an increased risk for sporadic AD (SAD) in European population. In the present study, we examined the association of the SOAT1 rs1044925 polymorphism with SAD in our northern Han-Chinese (107 cases, 118 age and gender-matched controls) sample using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. There was no genotypic (chi(2)=0.030, OR 0.942, 95% CI=0.478-1.857) or allelic (chi(2)=0.021, OR 0.955, 95% CI=0.508-1.794) association between SAD and controls, even when the data were stratified by APOE epsilon 4 carrier status. Our results indicate that the polymorphism rs1044925 in the 3′UTR of SOAT1 gene does not affect the risk of SAD in the northern Han-Chinese. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000231743100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67915
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Chinese Natl Human Genome Ctr, Beijing, Peoples R China
2.Capital Univ Med Sci, Xuanwu Hosp, Beijing Inst Geriatr, Beijing 100053, Peoples R China
3.Peking Univ, Hosp 1, Dept Neurol, Beijing 100871, Peoples R China
4.Capital Univ Med Sci, Xuanwu Hosp, Dept Neurobiol & Neurol, Beijing 100053, Peoples R China

Recommended Citation:
Zhao, FG,Wang, YH,Yang, JF,et al. Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer′s disease in Chinese[J]. NEUROSCIENCE LETTERS,2005,388(1):17-20.
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