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学科主题: 临床医学
题名:
Intensive statin therapy for Chinese patients with coronary artery disease undergoing percutaneous coronary intervention (ISCAP study)
作者: Liu, Peng; Jiang, Jie; Li, Jianping; Hong, Tao; Zhang, Yan; Yu, Ronghui; Jia, Jia; Huo, Yong
关键词: percutaneous coronary intervention ; myocardial infarction ; stent ; statins
刊名: CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
发表日期: 2012-05-01
DOI: 10.1002/ccd.23171
卷: 79, 期:6, 页:967-971
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: PERIPROCEDURAL MYOCARDIAL-INFARCTION ; C-REACTIVE PROTEIN ; RANDOMIZED-TRIAL ; STENT IMPLANTATION ; UNSTABLE ANGINA ; ATORVASTATIN ; ATHEROSCLEROSIS ; INFLAMMATION ; ANGIOPLASTY ; REDUCTION
英文摘要:

Background: Myocardial necrosis is related to higher incidence of cardiovascular events and higher mortality rates during follow-up. Statins have been demonstrated to lower the risk of periprocedural myocardial infarction. The aim of this study is to evaluate the safety and efficacy of intensive statin therapy and the long-term outcome of patients in the Asian population. Study design: Approximately 1,100 patients with stable angina or non-ST elevation acute coronary syndrome undergoing selective percutaneous coronary intervention (PCI) are enrolled in this study. Patients are randomized either to the experimental group (80 mg atorvastatin 80 mg/day x 2 days before and 40 mg/day x 30 days after PCI) or to the control group (usual care). Creatine kinase-MB (CK-MB), troponin I (cTnI), and serum creatine are measured at 24 hours after the procedure. The total follow-up period is 6 months. The primary objective is to evaluate the efficacy of intensive atorvastatin treatment compared with usual care in reducing 30-day primary cardiovascular endpoints in patients undergoing selective PCI. Secondary endpoints are changes in myocardial biomarkers (cTnI, CK-MB) and hs-CRP, CIN morbidity, 6-month clinical outcomes, and safety. Conclusion: The result of the ISCAP study will provide important evidence on the efficacy and safety of periprocedural serial intensive statin treatment in Asian patients with coronary artery disease undergoing selective PCI. (C) 2011 Wiley Periodicals, Inc.

语种: 英语
项目资助者: China Medical Foundation
WOS记录号: WOS:000302907900023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67918
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Liu, Peng,Jiang, Jie,Li, Jianping,et al. Intensive statin therapy for Chinese patients with coronary artery disease undergoing percutaneous coronary intervention (ISCAP study)[J]. CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS,2012,79(6):967-971.
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