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Incidence and nature of cognitive decline over 1 year among HIV-infected former plasma donors in China
Cysique, Lucette A.1,8; Letendre, Scott L.2; Ake, Christopher1; Jin, Hua1,5; Franklin, Donald R.1; Gupta, Saurabh1; Shi, Chuan6; Yu, Xin6; Wu, Zunyou7; Abramson, Ian S.3,4; Grant, Igor1; Heaton, Robert K.1; HIV Neurobehav Res Ctr Grp
关键词antiretroviral therapy China highly active HIV/AIDS incidence studies longitudinal studies neurocognitive disorders neuropsychological tests
刊名AIDS
2010-04-24
DOI10.1097/QAD.0b013e32833336c8
24期:7页:983-990
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Infectious Diseases ; Virology
研究领域[WOS]Immunology ; Infectious Diseases ; Virology
关键词[WOS]COMBINATION ANTIRETROVIRAL THERAPY ; CENTRAL-NERVOUS-SYSTEM ; NEUROPSYCHOLOGICAL IMPAIRMENT ; NEUROCOGNITIVE IMPAIRMENT ; TREATED PATIENTS ; TEST-PERFORMANCE ; RISK-FACTORS ; DEMENTIA ; INDIVIDUALS ; OUTPATIENTS
英文摘要

Objective: To quantify and characterize the nature of cognitive change over 1 year in a cohort of HIV-positive former plasma donors in rural China.

Design: The present study is an observational cohort study.

Methods: One hundred and ninety-two HIV-positive and 101 demographically comparable HIV-negative individuals, all former plasma donors, who lived in a rural part of China, received comprehensive medical and neuropsychological examinations. At study entry, 56% of HIV-positive group was on combination antiretroviral treatment and 60.9% at follow-up. Multiple regression change score approach was used with the HIV-negative sample to develop norms for change that would be then applied to the HIV-positive participants. Follow-up test scores adjusted for the control group practice effect.

Results: Fifty-three HIV-positive individuals (27%) developed significant cognitive decline as compared with five (5%) HIV-negative individuals. Cognitive decline was predicted at baseline by AIDS status, lower nadir CD4, and worse processing speed; at follow-up, it was associated with lower current CD4 cell count and failure of viral suppression on combination antiretroviral treatment. Neuropsychological decline also was associated with decreased independence in activities of daily living. Using neuropsychological impairment scores that were corrected for ′practice′ on repeated testing, we found that among the decliners, 41.5% (N = 22) had incident impairment, whereas 38% (N = 20) declined within the impaired range and another 20.7% (N = 11) declined within the normal range.

Conclusion: The present study demonstrates that despite ongoing combination antiretroviral treatment, cognitive decline in HIV-positive people is common over a 1-year follow-up. Regression-based norms for change on western neuropsychological tests can be used to detect disease-related cognitive decline in a developing country. (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins

语种英语
WOS记录号WOS:000276567500006
项目编号5 R01 MH073433-04 ; MH62512
资助机构NIMH ; NIMH
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67919
专题北京大学精神卫生研究所
作者单位1.VA San Diego Healthcare Syst, San Diego, CA USA
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
4.Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
5.Univ Calif San Diego, Dept Math, La Jolla, CA 92093 USA
6.Univ Calif San Diego, HNRC, La Jolla, CA 92093 USA
7.Natl Ctr AIDS STD Control & Prevent NCAIDS, Beijing, Peoples R China
8.Univ New S Wales, Dept Psychiat, Sydney, NSW, Australia
推荐引用方式
GB/T 7714
Cysique, Lucette A.,Letendre, Scott L.,Ake, Christopher,et al. Incidence and nature of cognitive decline over 1 year among HIV-infected former plasma donors in China[J]. AIDS,2010,24(7):983-990.
APA Cysique, Lucette A..,Letendre, Scott L..,Ake, Christopher.,Jin, Hua.,Franklin, Donald R..,...&HIV Neurobehav Res Ctr Grp.(2010).Incidence and nature of cognitive decline over 1 year among HIV-infected former plasma donors in China.AIDS,24(7),983-990.
MLA Cysique, Lucette A.,et al."Incidence and nature of cognitive decline over 1 year among HIV-infected former plasma donors in China".AIDS 24.7(2010):983-990.
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