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学科主题临床医学
Expression of beta-catenin in renal cell carcinoma
Zang, T; Zhuang, LY; Zhang, ZW; Xin, DQ; Guo, YL
关键词kidney neoplasm carcinoma beta-catenin
刊名CHINESE MEDICAL JOURNAL
2001-02-01
114期:2页:152-154
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]MUTATIONS ; TUMORS
英文摘要

Objective To investigate the expression of beta -catenin and its mRNA in renal cell carcinoma.

Methods Twenty-six cases with renal cell carcinoma (RCC) were studied by immunohistochemistry, Western blot and RT-PCR.

Results We found the expression of beta -catenis is higher in cancer tissues than in normal kidney tissues and the level of beta -catenin is associated with the tumor stage. Its expression in tumor of pT3 and pT4 is obviously higher than pT1 and pT2 (P<0.01). That is to say, there was an overexpression of -catenin protein in RCC and its level was related to the tumor stage, but the expression of beta -catenin mRNA had no difference between tumor tissue and normal tissue.

Conclusion beta -catenin may be related to the occurrence and progress of RCC.

语种英语
WOS记录号WOS:000167246700010
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67923
专题北京大学第一临床医学院_泌尿外科
作者单位1.Beijing Med Univ, Inst Urol, Beijing 100034, Peoples R China
2.Beijing Med Univ, Dept Physiol, Beijing 100083, Peoples R China
3.Beijing Med Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
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GB/T 7714
Zang, T,Zhuang, LY,Zhang, ZW,et al. Expression of beta-catenin in renal cell carcinoma[J]. CHINESE MEDICAL JOURNAL,2001,114(2):152-154.
APA Zang, T,Zhuang, LY,Zhang, ZW,Xin, DQ,&Guo, YL.(2001).Expression of beta-catenin in renal cell carcinoma.CHINESE MEDICAL JOURNAL,114(2),152-154.
MLA Zang, T,et al."Expression of beta-catenin in renal cell carcinoma".CHINESE MEDICAL JOURNAL 114.2(2001):152-154.
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