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学科主题: 药学
题名:
Lanthanum induces extracellular signal-regulated kinase phosphorylation through different mechanisms in HeLa cells and NIH 3T3 cells
作者: Hu, J; Yu, SW; Yang, XD; Wang, K; Qian, ZM
关键词: calcium ; extracellular signal-regulated kinase ; lanthanum ; phosphorylation
刊名: BIOMETALS
发表日期: 2006-02-01
DOI: 10.1007/s10534-005-3182-3
卷: 19, 期:1, 页:13-18
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: HUMAN ERYTHROCYTE-MEMBRANE ; CALCIUM-SENSING RECEPTOR ; SMOOTH-MUSCLE CELLS ; RAS/RAF/MEK/ERK PATHWAY ; PROTEIN-KINASES ; CALMODULIN ; APOPTOSIS ; CASCADE ; ACTIVATION ; RELEASE
英文摘要:

Lanthanum ion (La3+) was generally regarded as calcium antagonist and was used as calcium channel blocker. However, its potential biological effects on cells were poorly understood. In the present work, it was found that La3+ could induce rapid extracellular signal-regulated kinase (ERK) phosphorylation in both HeLa cells and NIH 3T3 cells, but different mechanisms were involved. At a concentration of 30 mu M or higher, La3+ enters the cells and activates ERK through a mechanism involving calmodulin activation inside the cells, which is similar to the action of intracellular Ca2+. However, at lower concentration, free La3+ promoted ERK phosphorylation in NIH 3T3 cells outside the cells through an unknown La3+ sensing mechanism, while Ca2+ exerted much weaker effect. The present results suggested that the biological effects of La3+ on cells maybe involve mechanisms beyond calcium antagonist.

语种: 英语
WOS记录号: WOS:000235634100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67927
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Natl Res Labs Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China

Recommended Citation:
Hu, J,Yu, SW,Yang, XD,et al. Lanthanum induces extracellular signal-regulated kinase phosphorylation through different mechanisms in HeLa cells and NIH 3T3 cells[J]. BIOMETALS,2006,19(1):13-18.
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