北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 期刊论文
学科主题: 临床医学
题名:
Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling
作者: Zhang, Yue-Zheng2,3; Zhang, Lian-Hai4; Gao, Yang2; Li, Chao-Hua2; Jia, Shu-Qin4; Liu, Ni4; Cheng, Feng2; Niu, De-Yun2,3; Cho, William C. S.5; Ji, Jia-Fu4; Zeng, Chang-Qing1,6
关键词: Gastric cancer ; Gene expression profiling ; Survival markers ; Prognosis ; Ribosomal proteins
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2011-04-07
DOI: 10.3748/wjg.v17.i13.1710
卷: 17, 期:13, 页:1710-1717
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: RIBOSOMAL-PROTEIN L19 ; COLORECTAL-CANCER ; BREAST-CANCER ; SURVIVAL ; PREDICTION ; RESECTION ; ADENOCARCINOMA ; METASTASIS ; RECURRENCE ; CELLS
英文摘要:

AIM: To develop a prognostic gene set that can predict patient overall survival status based on the whole genome expression analysis.

METHODS: Using Illumina HumanWG-6 BeadChip followed by semi-supervised analysis, we analyzed the expression of 47 296 transcripts in two batches of gastric cancer patients who underwent surgical resection. Thirty-nine samples in the first batch were used as the training set to discover candidate markers correlated to overall survival, and thirty-three samples in the second batch were used for validation.

RESULTS: A panel of ten genes were identified as prognostic marker in the first batch samples and classified patients into a low- and a high-risk group with significantly different survival times (P = 0.000047). This prognostic marker was then verified in an independent validation sample batch (P = 0.0009). By comparing with the traditional Tumor-node-metastasis (TNM) staging system, this ten-gene prognostic marker showed consistent prognosis results. It was the only independent prognostic value by multivariate Cox regression analysis (P = 0.007). Interestingly, six of these ten genes are ribosomal proteins, suggesting a possible association between the deregulation of ribosome related gene expression and the poor prognosis.

CONCLUSION: A ten-gene marker correlated with overall prognosis, including 6 ribosomal proteins, was identified and verified, which may complement the predictive value of TNM staging system. (C) 2011 Baishideng. All rights reserved.

语种: 英语
所属项目编号: SQ2009AA02-XK1482570 ; 2006AA02A402 ; D0905001040631 ; 2007-2051
项目资助者: National 863 Program ; Beijing Municipal Committee of Science and Technology ; Beijing Capital Development Foundation of Health Bureau
WOS记录号: WOS:000289455700008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67931
Appears in Collections:北京大学临床肿瘤学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genome Sci & Informat, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100029, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
4.Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res,Dept Surg, Minist Educ,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
5.Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
6.Chinese Acad Sci, Lab Canc Genom & Personalized Med, Beijing Inst Genom, Beijing 100029, Peoples R China

Recommended Citation:
Zhang, Yue-Zheng,Zhang, Lian-Hai,Gao, Yang,et al. Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2011,17(13):1710-1717.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Yue-Zheng]'s Articles
[Zhang, Lian-Hai]'s Articles
[Gao, Yang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Yue-Zheng]‘s Articles
[Zhang, Lian-Hai]‘s Articles
[Gao, Yang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace