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学科主题: 临床医学
题名:
Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling
作者: Zhang, Yue-Zheng2,3; Zhang, Lian-Hai4; Gao, Yang2; Li, Chao-Hua2; Jia, Shu-Qin4; Liu, Ni4; Cheng, Feng2; Niu, De-Yun2,3; Cho, William C. S.5; Ji, Jia-Fu4; Zeng, Chang-Qing1,6
关键词: Gastric cancer ; Gene expression profiling ; Survival markers ; Prognosis ; Ribosomal proteins
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2011-04-07
DOI: 10.3748/wjg.v17.i13.1710
卷: 17, 期:13, 页:1710-1717
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: RIBOSOMAL-PROTEIN L19 ; COLORECTAL-CANCER ; BREAST-CANCER ; SURVIVAL ; PREDICTION ; RESECTION ; ADENOCARCINOMA ; METASTASIS ; RECURRENCE ; CELLS
英文摘要:

AIM: To develop a prognostic gene set that can predict patient overall survival status based on the whole genome expression analysis.

METHODS: Using Illumina HumanWG-6 BeadChip followed by semi-supervised analysis, we analyzed the expression of 47 296 transcripts in two batches of gastric cancer patients who underwent surgical resection. Thirty-nine samples in the first batch were used as the training set to discover candidate markers correlated to overall survival, and thirty-three samples in the second batch were used for validation.

RESULTS: A panel of ten genes were identified as prognostic marker in the first batch samples and classified patients into a low- and a high-risk group with significantly different survival times (P = 0.000047). This prognostic marker was then verified in an independent validation sample batch (P = 0.0009). By comparing with the traditional Tumor-node-metastasis (TNM) staging system, this ten-gene prognostic marker showed consistent prognosis results. It was the only independent prognostic value by multivariate Cox regression analysis (P = 0.007). Interestingly, six of these ten genes are ribosomal proteins, suggesting a possible association between the deregulation of ribosome related gene expression and the poor prognosis.

CONCLUSION: A ten-gene marker correlated with overall prognosis, including 6 ribosomal proteins, was identified and verified, which may complement the predictive value of TNM staging system. (C) 2011 Baishideng. All rights reserved.

语种: 英语
所属项目编号: SQ2009AA02-XK1482570 ; 2006AA02A402 ; D0905001040631 ; 2007-2051
项目资助者: National 863 Program ; Beijing Municipal Committee of Science and Technology ; Beijing Capital Development Foundation of Health Bureau
WOS记录号: WOS:000289455700008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67931
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genome Sci & Informat, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100029, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
4.Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res,Dept Surg, Minist Educ,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
5.Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
6.Chinese Acad Sci, Lab Canc Genom & Personalized Med, Beijing Inst Genom, Beijing 100029, Peoples R China

Recommended Citation:
Zhang, Yue-Zheng,Zhang, Lian-Hai,Gao, Yang,et al. Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2011,17(13):1710-1717.
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