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学科主题临床医学
HACE1 Is a Tumor Suppressor Gene Candidate in Natural Killer Cell Neoplasms
Kuecuek, Can1; Hu, Xiaozhou1,5; Iqbal, Javeed1; Gaulard, Philippe6; Klinkebiel, David2; Cornish, Adam3; Dave, Bhavana J.4; Chan, Wing C.1
刊名AMERICAN JOURNAL OF PATHOLOGY
2013
DOI10.1016/j.ajpath.2012.09.012
182期:1页:49-55
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]LIGASE HACE1 ; ABERRANT METHYLATION ; NK-CELL ; CANCER ; LYMPHOMAS ; PRDM1 ; MALIGNANCIES ; CHROMOSOME ; EXPRESSION ; RAC1
英文摘要

HACE1 is an E3 ubiquitin ligase located in 6q21, the genomic region frequently deleted in natural killer (NK) cell malignancies. Here, we report HACE1 as a candidate tumor suppressor gene silenced through a combination of deletion and cytosine phosphate guanine island hypermethylation. We detected deletion of HACE1 in malignant NK cell lines (6 of 9, 67%) and primary biopsies (5 of 15, 33%) by quantitative PCR, with most of the specimen showing cytosine phosphate guanine island hypermethylation in the remaining allele, Leading to Low mRNA transcription. The ectopic expression of HACE1 in an HACE1-null NK cell Line led to apoptosis and G(2)/M cell cycle arrest. Moreover, HACE1 expression was up-regulated in IL-2-activated normal NK cells and NK cells cocultured with an engineered NK cell target, K562 Clone 9.mbIL21, suggesting its rote in the regulation of NK cell homeostasis. In conclusion, HACE1 is another potent tumor suppressor gene located within the 6q21 region, and loss of function of multiple tumor suppressor genes within 6q21 may be a critical determinant of NK cell Lymphomagenesis. (Am J Pathol 2013, 182: 49-55; http://dx.doi.org/10.1016/j.ajpath.2012.09.012)

语种英语
WOS记录号WOS:000313144000007
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67936
专题北京大学第三临床医学院
作者单位1.Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA
2.Univ Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE USA
3.Univ Nebraska Med Ctr, Dept Genet Cell Biol & Anat, Omaha, NE USA
4.Univ Nebraska Med Ctr, Ctr Human Genet, Omaha, NE USA
5.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100871, Peoples R China
6.Univ Paris Est, Grp Henri Mondor Albert Chenevier, Dept Pathol, INSERM,U955, Creteil, France
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GB/T 7714
Kuecuek, Can,Hu, Xiaozhou,Iqbal, Javeed,et al. HACE1 Is a Tumor Suppressor Gene Candidate in Natural Killer Cell Neoplasms[J]. AMERICAN JOURNAL OF PATHOLOGY,2013,182(1):49-55.
APA Kuecuek, Can.,Hu, Xiaozhou.,Iqbal, Javeed.,Gaulard, Philippe.,Klinkebiel, David.,...&Chan, Wing C..(2013).HACE1 Is a Tumor Suppressor Gene Candidate in Natural Killer Cell Neoplasms.AMERICAN JOURNAL OF PATHOLOGY,182(1),49-55.
MLA Kuecuek, Can,et al."HACE1 Is a Tumor Suppressor Gene Candidate in Natural Killer Cell Neoplasms".AMERICAN JOURNAL OF PATHOLOGY 182.1(2013):49-55.
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