IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
The origins and genetic structure of three co-resident Chinese Muslim populations: the Salar, Bo′an and Dongxiang
Wang, W; Wise, C; Baric, T; Black, ML; Bittles, AH
刊名HUMAN GENETICS
2003-08-01
DOI10.1007/s00439-003-0948-y
113期:3页:244-252
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]MITOCHONDRIAL-DNA ; HUMANS ; ASIA ; CONSANGUINITY ; HAPLOTYPES ; MIGRATION ; PAKISTAN
英文摘要

A genome-based investigation of three Muslim populations, the Salar, Bo′an, and Dongxiang, was conducted on 212 individuals (148 males, 64 females) coresident in Jishisan County, a minority autonomous region located in the province of Gansu, PR China. The Salar are believed to be of Turkic origin, whereas the Bo′an and Dongxiang both speak Mongolian. Biparental dinucleotide markers on chromosomes 13 and 15 indicated elevated mean homozygosity in the Salar (0.32), Bo′an (0.32), and Dongxiang (0.27), equivalent to inbreeding coefficients (F-is) of 0.16; 0.12; 0.01, confirming varying levels of endogamous and consanguineous marriage in all three communities. Y-chromosome unique event polymorphisms (UEPs) showed that males in the three communities shared common ancient origins, with 80-90% of haplotypes in common. However, the high levels of community-specific Y-chromosome STR haplotypes strongly suggested the action(s) of founder effect, genetic drift and preferential consanguinity during more recent historical time. By comparison with the marked inter-community differentiation revealed by the Y-chromosome STRs (29.4%), the mtDNA data indicated similarity between the female lineages of each community with just 1.2% inter-community variation. The combined use of these different marker systems gives an in-depth historical perspective, and provides evidence of past inter-marriage between genetically diverse male founders of each community and Han Chinese females with subsequent community endogamy.

语种英语
WOS记录号WOS:000184807600007
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67941
Collection北京大学深圳医院
作者单位1.Edith Cowan Univ, Ctr Human Genet, Perth, WA 6027, Australia
2.Peking Univ Hong Kong Univ Sci & Technol, Med Ctr, Shenzhen 518036, Peoples R China
Recommended Citation
GB/T 7714
Wang, W,Wise, C,Baric, T,et al. The origins and genetic structure of three co-resident Chinese Muslim populations: the Salar, Bo′an and Dongxiang[J]. HUMAN GENETICS,2003,113(3):244-252.
APA Wang, W,Wise, C,Baric, T,Black, ML,&Bittles, AH.(2003).The origins and genetic structure of three co-resident Chinese Muslim populations: the Salar, Bo′an and Dongxiang.HUMAN GENETICS,113(3),244-252.
MLA Wang, W,et al."The origins and genetic structure of three co-resident Chinese Muslim populations: the Salar, Bo′an and Dongxiang".HUMAN GENETICS 113.3(2003):244-252.
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