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Neuroprotection by Manganese Superoxide Dismutase (MnSOD) Mimics: Antioxidant Effect and Oxidative Stress Regulation in Acute Experimental Stroke
Huang, Hai-Feng; Guo, Fei; Cao, Yuan-Zhao; Shi, Wen; Xia, Qing
关键词Ischemic stroke Manganese superoxide dismutase Middle cerebral artery occlusion Neuroprotection
刊名CNS NEUROSCIENCE & THERAPEUTICS
2012-10-01
DOI10.1111/j.1755-5949.2012.00380.x
18期:10页:811-818
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]CEREBRAL-ARTERY OCCLUSION ; RAT CORTICAL-NEURONS ; ENDOPLASMIC-RETICULUM ; IN-VIVO ; MITOCHONDRIAL-FUNCTION ; HYDROGEN-PEROXIDE ; PROTECTS NEURONS ; ISCHEMIC-STROKE ; INJURY ; BRAIN
英文摘要

Aims Manganese superoxide dismutase (MnSOD), one of the most crucial antioxidant enzymes in the central nervous system, is thought to be one of the major mechanisms by which cells counteract the injuries of reactive oxygen species after cerebral ischemia. In this study, we used a novel synthesized compound (MnTm4PyP) with highly effective superoxide dismutase activity to study the therapeutic potential of MnSOD and the possible underlying mechanisms in cerebral ischemia. Methods Primary cultured cortical neurons were used to examine the protective effect of the compounds. Mice with middle cerebral artery occlusion were used as ischemic stroke animal model. Animals were pretreated with MnTm4PyP intravenously 30 similar to min before surgery. At 24 similar to h after surgery, neurological behavior and histological function were observed. Infarcted cortex tissues and cultured neurons were collected for investigation of the oxidative stress signaling pathways. Results In vitro studies revealed that MnSOD mimic MnTm4PyP pretreatment significantly increased viability of neurons after injury by H2O2. Intracellular superoxide radical levels were eliminated. In vivo experiments demonstrated MnTm4PyP pretreatment reduced infarct volume and improved neurological function. The MnSOD mimic alleviated oxidative stress and apoptosis. Conclusion MnSOD is an effective therapeutic target in ischemic stroke prevention because of its antioxidant effects and oxidative stress regulation.

语种英语
WOS记录号WOS:000309186000002
项目编号20901005 ; 2010010 ; 2010CB12300
资助机构National Natural Science Foundation of China ; Beijing Nova Program ; National Basic Research Program of China
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67948
专题北京大学药学院_化学生物学系
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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GB/T 7714
Huang, Hai-Feng,Guo, Fei,Cao, Yuan-Zhao,et al. Neuroprotection by Manganese Superoxide Dismutase (MnSOD) Mimics: Antioxidant Effect and Oxidative Stress Regulation in Acute Experimental Stroke[J]. CNS NEUROSCIENCE & THERAPEUTICS,2012,18(10):811-818.
APA Huang, Hai-Feng,Guo, Fei,Cao, Yuan-Zhao,Shi, Wen,&Xia, Qing.(2012).Neuroprotection by Manganese Superoxide Dismutase (MnSOD) Mimics: Antioxidant Effect and Oxidative Stress Regulation in Acute Experimental Stroke.CNS NEUROSCIENCE & THERAPEUTICS,18(10),811-818.
MLA Huang, Hai-Feng,et al."Neuroprotection by Manganese Superoxide Dismutase (MnSOD) Mimics: Antioxidant Effect and Oxidative Stress Regulation in Acute Experimental Stroke".CNS NEUROSCIENCE & THERAPEUTICS 18.10(2012):811-818.
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