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学科主题: 临床医学
题名:
Ras and Myc can drive oncogenic cell proliferation through individual D-cyclins
作者: Yu, QY; Ciemerych, MA; Sicinski, P
关键词: D-cyclins ; oncogenic transformation ; Ras ; Myc
刊名: ONCOGENE
发表日期: 2005-10-27
DOI: 10.1038/sj.onc.1208853
卷: 24, 期:47, 页:7114-7119
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
关键词[WOS]: BREAST-CANCER CELLS ; TRANSCRIPTIONAL INDUCTION ; EXPRESSION ; GENE ; TRANSFORMATION ; PATHWAY ; KINASE ; PROTEIN ; MOUSE ; PHOSPHORYLATION
英文摘要:

D-type cyclins serve as cell cycle recipients of several oncogenic pathways. The specific sequences of the promoters of the cyclin D genes are thought to render particular D-cyclins responsive to specific oncogenic pathways. For instance, the Ras oncogene was postulated to signal through cyclin D1, while Myc can impact the cell cycle machinery by transcriptionally upregulating cyclin D2. In the current study we engineered mouse fibroblasts to express only cyclin D1, only D2, or only D3. These ′single-cyclin′ cells allowed us to rigorously test the ability of cyclin D1, D2, or D3, when expressed on their own, to serve as recipients of the Ras- and Myc-driven oncogenic pathways. We found that each of the D-cyclins was sufficient to drive oncogenic proliferation of mouse fibroblasts. This, together with our recent observations that cells lacking all three D-cyclins show greatly reduced susceptibility to the oncogenic action of Ras and Myc, reveals that the Ras and Myc oncogenes can impact the core cell cycle machinery through all three D-cyclins.

语种: 英语
WOS记录号: WOS:000232833200013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67949
Appears in Collections:北京大学临床肿瘤学院_细胞生物学研究室_期刊论文

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作者单位: 1.Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
2.Univ Warsaw, Inst Zool, Dept Embryol, PL-02089 Warsaw, Poland
3.Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
4.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Cell Biol, Beijing 100034, Peoples R China

Recommended Citation:
Yu, QY,Ciemerych, MA,Sicinski, P. Ras and Myc can drive oncogenic cell proliferation through individual D-cyclins[J]. ONCOGENE,2005,24(47):7114-7119.
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