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High expression of inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia
Shi, Jin-long1; Fu, Lin2,3; Wang, Wei-dong1
关键词ITPR2 expression prognostic biomarker cytogenetically normal acute myeloid leukemia
刊名ONCOTARGET
2015-03-10
6期:7页:5299-5309
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Cell Biology
研究领域[WOS]Oncology ; Cell Biology
关键词[WOS]OLDER PATIENTS ; NPM1 MUTATIONS ; GROUP-B ; GENE ; PROFILES ; ASSOCIATION ; CANCER ; CELLS ; BAALC ; FLT3
英文摘要

Inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) is a key regulator for the activity of calcium ion transmembrane transportation, which plays a critical role in cell cycle and proliferation. However, the clinical impact of ITPR2 in cytogenetically normal acute myeloid leukemia (CN-AML) remained unknown. Several microarray datasets were used to evaluate the association between ITPR2 expression and clinical and molecular characteristics. ITPR2 showed a higher expression in CN-AML patients than normal persons. In a cohort of 157 CN-AML patients, high ITPR2 expression (ITPR2(high)) was associated with dramatically shorter overall survival (OS; P = 0.004) and event-free survival (EFS; P = 0.01), which were also shown in the European Leukemia Net (ELN) intermediate-I genetic category (OS: P = 0.0066; EFS: P = 0.009). Multivariable analyses adjusting for known prognostic factors confirmed ITPR2(high) to be associated with shorter OS (P = 0.0019) and EFS (P = 0.012). The prognostic value of ITPR2 was further validated in another cohort of 162 CN-AML patients (P = 0.007). In addition, first gene/microRNA expression signatures were derived that associated with ITPR2(high) on the genome-wide scale, which provided many indications to illustrate the possible mechanisms why ITPR2 could function. These results could aid to identify new targets and design novel therapeutic strategies for CN-AML patients.

语种英语
WOS记录号WOS:000352792000054
项目编号61372047 ; 2013BAI03B04
资助机构National Natural Science Foundation of China ; National High-tech R&amp ; D Program of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67953
专题北京大学第三临床医学院_血液内科
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Med Engn Support Ctr, Beijing 100853, Peoples R China
2.Peking Univ, Dept Hematol, Beijing 100191, Peoples R China
3.Peking Univ, Lymphoma Res Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Shi, Jin-long,Fu, Lin,Wang, Wei-dong. High expression of inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia[J]. ONCOTARGET,2015,6(7):5299-5309.
APA Shi, Jin-long,Fu, Lin,&Wang, Wei-dong.(2015).High expression of inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia.ONCOTARGET,6(7),5299-5309.
MLA Shi, Jin-long,et al."High expression of inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia".ONCOTARGET 6.7(2015):5299-5309.
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