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学科主题: 临床医学
题名:
High expression of inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia
作者: Shi, Jin-long1; Fu, Lin2,3; Wang, Wei-dong1
关键词: ITPR2 ; expression ; prognostic biomarker ; cytogenetically normal acute myeloid leukemia
刊名: ONCOTARGET
发表日期: 2015-03-10
卷: 6, 期:7, 页:5299-5309
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: OLDER PATIENTS ; NPM1 MUTATIONS ; GROUP-B ; GENE ; PROFILES ; ASSOCIATION ; CANCER ; CELLS ; BAALC ; FLT3
英文摘要:

Inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) is a key regulator for the activity of calcium ion transmembrane transportation, which plays a critical role in cell cycle and proliferation. However, the clinical impact of ITPR2 in cytogenetically normal acute myeloid leukemia (CN-AML) remained unknown. Several microarray datasets were used to evaluate the association between ITPR2 expression and clinical and molecular characteristics. ITPR2 showed a higher expression in CN-AML patients than normal persons. In a cohort of 157 CN-AML patients, high ITPR2 expression (ITPR2(high)) was associated with dramatically shorter overall survival (OS; P = 0.004) and event-free survival (EFS; P = 0.01), which were also shown in the European Leukemia Net (ELN) intermediate-I genetic category (OS: P = 0.0066; EFS: P = 0.009). Multivariable analyses adjusting for known prognostic factors confirmed ITPR2(high) to be associated with shorter OS (P = 0.0019) and EFS (P = 0.012). The prognostic value of ITPR2 was further validated in another cohort of 162 CN-AML patients (P = 0.007). In addition, first gene/microRNA expression signatures were derived that associated with ITPR2(high) on the genome-wide scale, which provided many indications to illustrate the possible mechanisms why ITPR2 could function. These results could aid to identify new targets and design novel therapeutic strategies for CN-AML patients.

语种: 英语
所属项目编号: 61372047 ; 2013BAI03B04
项目资助者: National Natural Science Foundation of China ; National High-tech R&amp ; D Program of China
WOS记录号: WOS:000352792000054
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67953
Appears in Collections:北京大学第三临床医学院_血液内科_期刊论文

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作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Med Engn Support Ctr, Beijing 100853, Peoples R China
2.Peking Univ, Dept Hematol, Beijing 100191, Peoples R China
3.Peking Univ, Lymphoma Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Shi, Jin-long,Fu, Lin,Wang, Wei-dong. High expression of inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia[J]. ONCOTARGET,2015,6(7):5299-5309.
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