IR@PKUHSC  > 北京大学第二临床医学院  > 肝胆外科
学科主题临床医学
Hepatocellular carcinoma patients highly and specifically expressing XAGE-1 exhibit prolonged survival
Gong, Lei; Peng, Jirun; Cui, Zhuqingqing; Chen, Pengcheng; Han, Hui; Zhang, Dafang; Leng, Xisheng
关键词hepatocellular carcinoma XAGE-1 cancer/testis antigen
刊名ONCOLOGY LETTERS
2010-11-01
DOI10.3892/ol.2010.175
1期:6页:1083-1088
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CANCER/TESTIS CT ANTIGENS ; CD4 T-CELLS ; LUNG-CANCER ; PROSTATE-CANCER ; ANTIBODY-RESPONSE ; EWINGS-SARCOMA ; IDENTIFICATION ; GENE ; ADENOCARCINOMA ; FAMILY
英文摘要

XA.GE-1 is classified into the group of a new family of cancer-testis antigens (CTA) and has the four transcript variants of X AGE-la, XAGE-1b, XAGE-1c and XAGE-1d. Immunohistochemistry was used to investigate the expression of XAGE-1 transcript variants in Chinese patients with hepatocellular carcinoma (HCC). Reverse transcription-polymerase chain reaction (RT-PCR) and real-time RT-PCR were used to analyze XAGE-1 gene expression, and XAGE-1 protein expression was examined by immunohistochemistry. Furthermore, the clinical correlation of XAGE-1 expression was analyzed. The expression of the XAGE-I mRNA was investigated in the tissues of 96 HCC patients and all XAGE-1 isoforms were detected in these tissues. Three types of XAGE-1 transcript variants (XAGE-1b, XAGE-le and XAGE-Id) showed high specific and frequent expression in HCC tissues, with the positive expression rate of XAGE-1b, XAGE-1c and XAGE-1d being 41.7% (40/96), 15.6% (15/96) and 26.0% (25/96), respectively. XAGE-1b was the dominant type, but none of the three were detected in adjacent non-HCC tissues. Only 2 cases of XAGE-I a mRNA expression were observed. Moreover, XAGE-1 protein was detected in 39 of 96 HCC patients, but none in the adjacent non-cancerous tissue and normal liver tissue. No relationship was found between the expression of XAGE-1 and clinical parameters, such as age, gender, tumor size, TNM staging, serum AFP level and infection with hepatitis virus. Patients with XAGE-1b-positive transcript variant exhibited shorter 2-year survival times. The high frequency and specificity of XAGE-1, particularly XAGE-1b, in HCC indicates that their products may predict the prognosis of HCC patients and be novel targets for antigen-specific immunotherapy to HCC.

语种英语
WOS记录号WOS:000284800700028
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67954
专题北京大学第二临床医学院_肝胆外科
作者单位Peking Univ, Peoples Hosp, Dept Hepatobiliary Surg, Beijing 100044, Peoples R China
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GB/T 7714
Gong, Lei,Peng, Jirun,Cui, Zhuqingqing,et al. Hepatocellular carcinoma patients highly and specifically expressing XAGE-1 exhibit prolonged survival[J]. ONCOLOGY LETTERS,2010,1(6):1083-1088.
APA Gong, Lei.,Peng, Jirun.,Cui, Zhuqingqing.,Chen, Pengcheng.,Han, Hui.,...&Leng, Xisheng.(2010).Hepatocellular carcinoma patients highly and specifically expressing XAGE-1 exhibit prolonged survival.ONCOLOGY LETTERS,1(6),1083-1088.
MLA Gong, Lei,et al."Hepatocellular carcinoma patients highly and specifically expressing XAGE-1 exhibit prolonged survival".ONCOLOGY LETTERS 1.6(2010):1083-1088.
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