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学科主题: 临床医学
题名:
Erythrocytic or serum hydrogen sulfide association with hypertension development in untreated essential hypertension
作者: Zheng Mei2; Zeng Qiang3; Shi Xiao-qin1; Zhao Jing1,4; Tang Chao-shu1,4; Sun Ning-ling2; Geng Bin1,4
关键词: erythrocyte ; hydrogen sulfide ; 3-mercaptopyruvate sulphurtransferase ; hypertension
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-11-20
DOI: 10.3760/cma.j.issn.0366-6999.2011.22.017
卷: 124, 期:22, 页:3693-3701
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: HIGH BLOOD-PRESSURE ; 3-MERCAPTOPYRUVATE SULFURTRANSFERASE ; NITRIC-OXIDE ; MERCAPTOPYRUVATE SULFURTRANSFERASE ; RATS ; H2S ; VASORELAXANT ; PATHOGENESIS ; TISSUE ; HEART
英文摘要:

Background Endogenous hydrogen sulfide (H(2)S) plays an important role in hypertension. The aim of this study was to investigate the role of erythrocyte and serum H(2)S in patients with untreated essential hypertension.

Methods We recruited 62 patients (age 22-74 years) with untreated prehypertension or hypertension, and 64 normotensive subjects (age 18-64 years). We assessed the 3-mercaptopyruvate sulphurtransferase (MPST) protein expression in erythrocytes and measured the H(2)S production from erythrocytes and serum H(2)S levels, then analyzed the association of erythrocytic or serum H(2)S content and blood pressure or cardiovascular risk factors (e.g., age, body mass index (BMI) and dyslipidemia). A stepwise regression analysis was used to evaluate the possible relationship of erythrocytic H(2)S in hypertension.

Results In hypertensive patients, erythrocyte H(2)S production ((111.04 +/- 29.20) nmol/min per 10(8) erythrocytes) was higher than that in controls ((78.85 +/- 19.38) nmol/min per 10(8) erythrocytes), and serum H(2)S was also higher. The erythrocytic H(2)S production was associated with increased systolic blood pressure (sBP), diastolic blood pressure (dBP), age, BMI, level of C-reactive protein (CRP), as well as triglycerides (TG) and high density lipoprotein cholesterol (HDL-C). Serum H(2)S was not associated with age or CRP. Stepwise regression analysis showed that erythrocytic H(2)S production was correlated with sBP, TG, HDL-C, low density lipoprotein cholesterol (LDL-C) and blood urea nitrogen (BUN) and serum H(2)S was correlated with dBP and TG. Results of receiver-operating characteristic curve analysis suggested that erythrocytic H(2)S production was a more sensitive predictor of hypertension development than serum H(2)S.

Conclusion Erythrocytic or serum H(2)S production is sensitive predictor of hypertension. Chin Med J 2011;124(22):3693-3701

语种: 英语
所属项目编号: 2006CB503807 ; 30971084 ; 30821001
项目资助者: Major State Basic Research Development Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000297658300017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67955
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiac Ctr, Beijing 100044, Peoples R China
3.Chinese Peoples Liberat Army, Gen Hosp, Dept Hlth Ctr, Beijing 100853, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China

Recommended Citation:
Zheng Mei,Zeng Qiang,Shi Xiao-qin,et al. Erythrocytic or serum hydrogen sulfide association with hypertension development in untreated essential hypertension[J]. CHINESE MEDICAL JOURNAL,2011,124(22):3693-3701.
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