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Gene expression profiles of hepatocytes treated with La(NO(3))(3) of rare earth in rats
Zhao, Hui1; Hao, Wei-Dong1; Xu, Hou-En1; Shang, Lan-Qin1; Lu, You-Yong2
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2004-06-01
10期:11页:1625-1629
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
英文摘要

AIM: To compare the gene expression between La(NO(3))(3)-exposed and control rats in vivo.

METHODS: Rats were fed La(NO(3))(3) once daily at a dose of 20 mg/kg for one month by gavage. Gene expression of hepatocytes was detected using mRNA differential display (DD) technique and cDNA microarray and compared between treated and control groups.

RESULTS: Six differentially expressed sequence tags were cloned by DD, of which five were up regulated and one was down regulated in treated rats. Two sequences were determined. One band was novel. The other shared 100% sequence homology with AU080263 Sugano mouse brain mncb Mus musculus cDNA clone MNCb-5435 5′. With DNA microarray, 136 differentially expressed genes were identified including 131 over-expressed genes and 5 under-expressed genes. Most of these differentially expressed genes were cell signal and transmission genes, genes associated with metabolism, protein translation and synthesis.

CONCLUSION: La(NO3) 3 could change the expression levels of some kinds of genes. Further analysis of the differentially expressed genes would be helpful for understanding the wide biological effect spectrum of rare earth elements.

语种英语
WOS记录号WOS:000208097000018
项目编号29890280-3
资助机构National Natural Science Foundation of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67958
专题北京大学公共卫生学院_毒理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Toxicol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Hui,Hao, Wei-Dong,Xu, Hou-En,et al. Gene expression profiles of hepatocytes treated with La(NO(3))(3) of rare earth in rats[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(11):1625-1629.
APA Zhao, Hui,Hao, Wei-Dong,Xu, Hou-En,Shang, Lan-Qin,&Lu, You-Yong.(2004).Gene expression profiles of hepatocytes treated with La(NO(3))(3) of rare earth in rats.WORLD JOURNAL OF GASTROENTEROLOGY,10(11),1625-1629.
MLA Zhao, Hui,et al."Gene expression profiles of hepatocytes treated with La(NO(3))(3) of rare earth in rats".WORLD JOURNAL OF GASTROENTEROLOGY 10.11(2004):1625-1629.
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