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学科主题: 公共卫生
题名:
Gene expression profiles of hepatocytes treated with La(NO(3))(3) of rare earth in rats
作者: Zhao, Hui1; Hao, Wei-Dong1; Xu, Hou-En1; Shang, Lan-Qin1; Lu, You-Yong2
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2004-06-01
卷: 10, 期:11, 页:1625-1629
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
英文摘要:

AIM: To compare the gene expression between La(NO(3))(3)-exposed and control rats in vivo.

METHODS: Rats were fed La(NO(3))(3) once daily at a dose of 20 mg/kg for one month by gavage. Gene expression of hepatocytes was detected using mRNA differential display (DD) technique and cDNA microarray and compared between treated and control groups.

RESULTS: Six differentially expressed sequence tags were cloned by DD, of which five were up regulated and one was down regulated in treated rats. Two sequences were determined. One band was novel. The other shared 100% sequence homology with AU080263 Sugano mouse brain mncb Mus musculus cDNA clone MNCb-5435 5′. With DNA microarray, 136 differentially expressed genes were identified including 131 over-expressed genes and 5 under-expressed genes. Most of these differentially expressed genes were cell signal and transmission genes, genes associated with metabolism, protein translation and synthesis.

CONCLUSION: La(NO3) 3 could change the expression levels of some kinds of genes. Further analysis of the differentially expressed genes would be helpful for understanding the wide biological effect spectrum of rare earth elements.

语种: 英语
所属项目编号: 29890280-3
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000208097000018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67958
Appears in Collections:北京大学公共卫生学院_毒理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Toxicol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100034, Peoples R China

Recommended Citation:
Zhao, Hui,Hao, Wei-Dong,Xu, Hou-En,et al. Gene expression profiles of hepatocytes treated with La(NO(3))(3) of rare earth in rats[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(11):1625-1629.
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