北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers
作者: Liu, Yu1; Sun, Hong-qiang1,2; Bao, Yan-ping1; Li, Su-xia1; Beveridge, Thomas J. R.3; Di, Xiao-lan2; Yang, Fu-de2; Lu, Lin1
关键词: Nicotine dependence ; Aripiprazole ; Dopamine partial agonist ; Smoking urge ; The response to smoking ; Cue exposure
刊名: DRUG AND ALCOHOL DEPENDENCE
发表日期: 2009-04-01
DOI: 10.1016/j.drugalcdep.2008.10.024
卷: 101, 期:1-2, 页:42-52
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Substance Abuse ; Psychiatry
研究领域[WOS]: Substance Abuse ; Psychiatry
关键词[WOS]: RANDOMIZED CONTROLLED-TRIAL ; DOPAMINE D-3 RECEPTOR ; NICOTINE REPLACEMENT THERAPY ; SUSTAINED-RELEASE BUPROPION ; EMERGING TOBACCO HAZARDS ; VENTRAL TEGMENTAL AREA ; PARTIAL AGONIST ; SMOKING-CESSATION ; D-AMPHETAMINE ; COCAINE-SEEKING
英文摘要:

Background: Drug addiction researchers have begun to study dopamine partial agonists as potential therapeutic agents. The partial dopamine D(2) receptor agonist aripiprazole has recently been tested as a treatment for stimulant and alcohol dependence in both animal and clinical Studies.

Methods: A randomized and placebo-controlled pilot clinical study was conducted in a population of Chinese light and heavy smokers to assess the effect of aripiprazole on various responses to smoking. The primary outcornes were subject′s ratings on questionnaires of smoking urge, withdrawal syndromes, and cigarette evaluation. Placebo, 5, and 10 mg aripiprazole were acutely administered in all participants, with administrations at least 7 days apart. Subjective responses to a smoked cigarette, working memory, and attention/psychomotor performance were assessed before and after drug administration in each experimental session. Abstinence-induced smoking urge, withdrawal symptoms, blood pressure, and heart rate were also measured every 45 min after drug administration. Finally, a cue-testing session was carried out 4 h after each drug administration.

Results: Administration of 10mg aripiprazole significantly decreased both the subjective response and psychological reward derived from smoking a cigarette in heavy smokers. While neither 5 nor 10 Mg aripiprazole significantly decreased abstinence-induced smoking urges or withdrawal symptoms in light and heavy smokers, these doses Substantially attenuated drug cue-induced smoking urges in heavy smokers. Aripiprazole did not affect working memory or attention/psychomotor performance.

Conclusions: Light and heavy smokers responded differently to aripiprazole across various dependent measures. AripipraZole may potentially affect various subjective responses to smoking in heavy smokers. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2007CB512302 ; 2006AA02Z4D1
项目资助者: Program for New Century Excellent Talents in University ; National Basic Research Program of China ; National High Technology Research and Development Program of China
WOS记录号: WOS:000264427200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67966
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Beijing Hui Long Guan Hosp, Dept Alcohol Dependence, Beijing 100096, Peoples R China
3.Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA

Recommended Citation:
Liu, Yu,Sun, Hong-qiang,Bao, Yan-ping,et al. Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers[J]. DRUG AND ALCOHOL DEPENDENCE,2009,101(1-2):42-52.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Yu]'s Articles
[Sun, Hong-qiang]'s Articles
[Bao, Yan-ping]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Yu]‘s Articles
[Sun, Hong-qiang]‘s Articles
[Bao, Yan-ping]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace