|Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers|
|Liu, Yu1; Sun, Hong-qiang1,2; Bao, Yan-ping1; Li, Su-xia1; Beveridge, Thomas J. R.3; Di, Xiao-lan2; Yang, Fu-de2; Lu, Lin1|
|关键词||Nicotine dependence Aripiprazole Dopamine partial agonist Smoking urge The response to smoking Cue exposure|
|刊名||DRUG AND ALCOHOL DEPENDENCE|
|WOS标题词||Science & Technology|
|类目[WOS]||Substance Abuse ; Psychiatry|
|研究领域[WOS]||Substance Abuse ; Psychiatry|
|关键词[WOS]||RANDOMIZED CONTROLLED-TRIAL ; DOPAMINE D-3 RECEPTOR ; NICOTINE REPLACEMENT THERAPY ; SUSTAINED-RELEASE BUPROPION ; EMERGING TOBACCO HAZARDS ; VENTRAL TEGMENTAL AREA ; PARTIAL AGONIST ; SMOKING-CESSATION ; D-AMPHETAMINE ; COCAINE-SEEKING|
Background: Drug addiction researchers have begun to study dopamine partial agonists as potential therapeutic agents. The partial dopamine D(2) receptor agonist aripiprazole has recently been tested as a treatment for stimulant and alcohol dependence in both animal and clinical Studies.
Methods: A randomized and placebo-controlled pilot clinical study was conducted in a population of Chinese light and heavy smokers to assess the effect of aripiprazole on various responses to smoking. The primary outcornes were subject′s ratings on questionnaires of smoking urge, withdrawal syndromes, and cigarette evaluation. Placebo, 5, and 10 mg aripiprazole were acutely administered in all participants, with administrations at least 7 days apart. Subjective responses to a smoked cigarette, working memory, and attention/psychomotor performance were assessed before and after drug administration in each experimental session. Abstinence-induced smoking urge, withdrawal symptoms, blood pressure, and heart rate were also measured every 45 min after drug administration. Finally, a cue-testing session was carried out 4 h after each drug administration.
Results: Administration of 10mg aripiprazole significantly decreased both the subjective response and psychological reward derived from smoking a cigarette in heavy smokers. While neither 5 nor 10 Mg aripiprazole significantly decreased abstinence-induced smoking urges or withdrawal symptoms in light and heavy smokers, these doses Substantially attenuated drug cue-induced smoking urges in heavy smokers. Aripiprazole did not affect working memory or attention/psychomotor performance.
Conclusions: Light and heavy smokers responded differently to aripiprazole across various dependent measures. AripipraZole may potentially affect various subjective responses to smoking in heavy smokers. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
|项目编号||2007CB512302 ; 2006AA02Z4D1|
|资助机构||Program for New Century Excellent Talents in University ; National Basic Research Program of China ; National High Technology Research and Development Program of China|
|作者单位||1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China|
2.Beijing Hui Long Guan Hosp, Dept Alcohol Dependence, Beijing 100096, Peoples R China
3.Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA
|Liu, Yu,Sun, Hong-qiang,Bao, Yan-ping,et al. Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers[J]. DRUG AND ALCOHOL DEPENDENCE,2009,101(1-2):42-52.|
|APA||Liu, Yu.,Sun, Hong-qiang.,Bao, Yan-ping.,Li, Su-xia.,Beveridge, Thomas J. R..,...&Lu, Lin.(2009).Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers.DRUG AND ALCOHOL DEPENDENCE,101(1-2),42-52.|
|MLA||Liu, Yu,et al."Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers".DRUG AND ALCOHOL DEPENDENCE 101.1-2(2009):42-52.|