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Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers
Liu, Yu1; Sun, Hong-qiang1,2; Bao, Yan-ping1; Li, Su-xia1; Beveridge, Thomas J. R.3; Di, Xiao-lan2; Yang, Fu-de2; Lu, Lin1
关键词Nicotine dependence Aripiprazole Dopamine partial agonist Smoking urge The response to smoking Cue exposure
刊名DRUG AND ALCOHOL DEPENDENCE
2009-04-01
DOI10.1016/j.drugalcdep.2008.10.024
101期:1-2页:42-52
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Substance Abuse ; Psychiatry
研究领域[WOS]Substance Abuse ; Psychiatry
关键词[WOS]RANDOMIZED CONTROLLED-TRIAL ; DOPAMINE D-3 RECEPTOR ; NICOTINE REPLACEMENT THERAPY ; SUSTAINED-RELEASE BUPROPION ; EMERGING TOBACCO HAZARDS ; VENTRAL TEGMENTAL AREA ; PARTIAL AGONIST ; SMOKING-CESSATION ; D-AMPHETAMINE ; COCAINE-SEEKING
英文摘要

Background: Drug addiction researchers have begun to study dopamine partial agonists as potential therapeutic agents. The partial dopamine D(2) receptor agonist aripiprazole has recently been tested as a treatment for stimulant and alcohol dependence in both animal and clinical Studies.

Methods: A randomized and placebo-controlled pilot clinical study was conducted in a population of Chinese light and heavy smokers to assess the effect of aripiprazole on various responses to smoking. The primary outcornes were subject′s ratings on questionnaires of smoking urge, withdrawal syndromes, and cigarette evaluation. Placebo, 5, and 10 mg aripiprazole were acutely administered in all participants, with administrations at least 7 days apart. Subjective responses to a smoked cigarette, working memory, and attention/psychomotor performance were assessed before and after drug administration in each experimental session. Abstinence-induced smoking urge, withdrawal symptoms, blood pressure, and heart rate were also measured every 45 min after drug administration. Finally, a cue-testing session was carried out 4 h after each drug administration.

Results: Administration of 10mg aripiprazole significantly decreased both the subjective response and psychological reward derived from smoking a cigarette in heavy smokers. While neither 5 nor 10 Mg aripiprazole significantly decreased abstinence-induced smoking urges or withdrawal symptoms in light and heavy smokers, these doses Substantially attenuated drug cue-induced smoking urges in heavy smokers. Aripiprazole did not affect working memory or attention/psychomotor performance.

Conclusions: Light and heavy smokers responded differently to aripiprazole across various dependent measures. AripipraZole may potentially affect various subjective responses to smoking in heavy smokers. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000264427200007
项目编号2007CB512302 ; 2006AA02Z4D1
资助机构Program for New Century Excellent Talents in University ; National Basic Research Program of China ; National High Technology Research and Development Program of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67966
专题北京大学精神卫生研究所_精神科
北京大学医学部管理机构_医学部
中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Beijing Hui Long Guan Hosp, Dept Alcohol Dependence, Beijing 100096, Peoples R China
3.Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA
推荐引用方式
GB/T 7714
Liu, Yu,Sun, Hong-qiang,Bao, Yan-ping,et al. Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers[J]. DRUG AND ALCOHOL DEPENDENCE,2009,101(1-2):42-52.
APA Liu, Yu.,Sun, Hong-qiang.,Bao, Yan-ping.,Li, Su-xia.,Beveridge, Thomas J. R..,...&Lu, Lin.(2009).Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers.DRUG AND ALCOHOL DEPENDENCE,101(1-2),42-52.
MLA Liu, Yu,et al."Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers".DRUG AND ALCOHOL DEPENDENCE 101.1-2(2009):42-52.
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