IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心
学科主题临床医学
Combined preoperative CEA and CD44v6 improves prognostic value in patients with stage I and stage II colorectal cancer
Chen, L.; Jiang, B.; Wang, Z.; Liu, M.; Yang, H.; Xing, J.; Zhang, C.; Yao, Z.; Zhang, N.; Cui, M.; Su, X.
关键词CEA CD44v6 Colorectal cancer Prognosis
刊名CLINICAL & TRANSLATIONAL ONCOLOGY
2014-03-01
DOI10.1007/s12094-013-1069-2
16期:3页:285-292
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; Capital Medical Development and Research Foundation ; Clinical Characteristics and Application Research of Capital (Beijing Municipal Science &amp ; Technology Commission) ; Beijing Natural Science Foundation ; New Star of Science and Technology Program of Beijing (Beijing Municipal Science &amp ; Technology Commission) ; National Natural Science Foundation of China ; Capital Medical Development and Research Foundation ; Clinical Characteristics and Application Research of Capital (Beijing Municipal Science &amp ; Technology Commission) ; Beijing Natural Science Foundation ; New Star of Science and Technology Program of Beijing (Beijing Municipal Science &amp ; Technology Commission)
研究领域[WOS]Oncology
关键词[WOS]CARCINOEMBRYONIC ANTIGEN LEVEL ; COLON-CANCER ; RECTAL-CANCER ; SERUM ; SURVIVAL ; EXPRESSION ; IMPACT
英文摘要

Combination of biomarkers may improve diagnosis and have better prognostic value than single markers. The purpose of this study was to investigate whether combined CEA and CD44v6 improves prognostic value in stage I and stage II (stage I/II) colorectal cancer (CRC).

Preoperative serum CEA level and the expression of CD44v6 in CRC tissues were examined by electrochemiluminescence immunoassay and immunohistochemistry, respectively. The association of CEA and CD44v6 with clinicopathological features and their possible prognostic values was analyzed.

The preoperative elevated serum CEA level and positive CD44v6 expression were detected in 30.1 % (52/173) serum samples and 60.5 % (101/167) CRC tissues, respectively. Patients with an elevated-CEA level or a CD44v6-negative tumor had a worse disease-specific survival (DSS) than those with a normal-CEA level or CD44v6-positive tumor (P = 0.024, P = 0.012, respectively). Moreover, CD44v6 expression could be used in discriminating patients from good to poor prognosis in normal-CEA subgroup (P = 0.043), but not in elevated-CEA subgroup (P = 0.563). Multivariate analysis revealed that combined CEA and CD44v6 was an independent prognostic factor for patients with stage I/II CRC (P = 0.023). However, serum CEA level only retained a borderline significance for correlation with a worse DSS (P = 0.059), and CD44v6 expression alone was not an independent prognostic factor for DSS in multivariate analysis (P = 0.123).

These results suggested that combined CEA/CD44v6 had better prognostic value than CEA or CD44v6 alone for patients with stage I/II CRC.

语种英语
所属项目编号81272766 ; 81071658 ; 2009-2093 ; Z121107001012130 ; 7132054 ; 2011060
资助者National Natural Science Foundation of China ; Capital Medical Development and Research Foundation ; Clinical Characteristics and Application Research of Capital (Beijing Municipal Science &amp ; Technology Commission) ; Beijing Natural Science Foundation ; New Star of Science and Technology Program of Beijing (Beijing Municipal Science &amp ; Technology Commission) ; National Natural Science Foundation of China ; Capital Medical Development and Research Foundation ; Clinical Characteristics and Application Research of Capital (Beijing Municipal Science &amp ; Technology Commission) ; Beijing Natural Science Foundation ; New Star of Science and Technology Program of Beijing (Beijing Municipal Science &amp ; Technology Commission)
WOS记录号WOS:000331631400008
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67974
专题北京大学临床肿瘤学院_胃肠肿瘤中心
作者单位Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Minimally Invas Gastrointestinal Surg, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China
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GB/T 7714
Chen, L.,Jiang, B.,Wang, Z.,et al. Combined preoperative CEA and CD44v6 improves prognostic value in patients with stage I and stage II colorectal cancer[J]. CLINICAL & TRANSLATIONAL ONCOLOGY,2014,16(3):285-292.
APA Chen, L..,Jiang, B..,Wang, Z..,Liu, M..,Yang, H..,...&Su, X..(2014).Combined preoperative CEA and CD44v6 improves prognostic value in patients with stage I and stage II colorectal cancer.CLINICAL & TRANSLATIONAL ONCOLOGY,16(3),285-292.
MLA Chen, L.,et al."Combined preoperative CEA and CD44v6 improves prognostic value in patients with stage I and stage II colorectal cancer".CLINICAL & TRANSLATIONAL ONCOLOGY 16.3(2014):285-292.
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