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Association of BDNF Val66Met Polymorphism with both baseline HRQOL scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine
Zou, Yan-Feng1; Wang, Yu2; Liu, Ping2; Feng, Xiao-Liang1,3; Wang, Bin-Yan2; Zang, Tong-Hua2; Yu, Xin4; Wei, Jing5; Liu, Zhong-Chun6; Liu, Ying7; Tao, Ming8; Li, Hui-Chun9; Li, Ke-Qing10; Hu, Jian11; Li, Ming12; Zhang, Ke-Rang13; Ye, Dong-Qing1; Xu, Xi-Ping2
关键词health related quality of life major depressive disorder brain-derived neurotrophic factor polymorphism SSRIs
刊名HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
2010-03-01
DOI10.1002/hup.1099
25期:2页:145-152
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Social Sciences
类目[WOS]Clinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
关键词[WOS]NEUROTROPHIC FACTOR BDNF ; QUALITY-OF-LIFE ; FACTOR GENE ; VAL(66)MET POLYMORPHISM ; TREATMENT-RESPONSE ; MEDICAL OUTCOMES ; BRAIN ; HEALTH ; SERUM ; DISORDERS
英文摘要

Objective To explore the association of brain-derived neurotrophic-factor (BDNF) Val66Met polymorphism with both baseline health related quality of life (HRQOL) scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine.

Methods Patients with major depressive disorder (MDD) took fluoxetine (20 mg/day) for 6 weeks. The HRQOL was measured with the Medical Outcomes Study Short Form-36 (SF-36) at baseline and at 6th week. Patients were genotyped for Val66Met polymorphism of BDNF gene.

Results There was a significant association between social function (SF) and BDNF Val66Met polymorphism, and patients with Met/Met genotype had better SF (compared with Val/Val P = 0.004; compared with Val/Met P = 0.005). A significant association was found between improvement in SF and BDNF Val66Met polymorphism, and patients with Met/Met genotype had poorer improvement in SF (compared with Val/Val P = 0.010; compared with Val/Met P = 0.001). Similar association was found between improvement in mental component summary (MCS) and BDNF Val66Met polymorphism, and patients with Met/Met genotype had poorer improvement in MCS (compared with Val/Val P = 0.066; compared with Val/Met P = 0.006).

Conclusions These results indicate that there may be association between BDNF Val66Met polymorphism and both baseline HRQOL (SF) scores and improvement in HRQOL (SF, MCS) scores in Chinese major depressive patients treated with fluoxetine. Copyright (C) 2010 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000276078100007
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67982
专题北京大学精神卫生研究所
作者单位1.Suzhou Guangji Hosp, Dept Psychiat, Suzhou, Zhejiang, Peoples R China
2.Anhui Med Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Hefei 230032, Anhui, Peoples R China
3.Anhui Med Univ, Inst Biomed, Hefei 230032, Anhui, Peoples R China
4.Anhui Med Univ, Dept Basic Med Sci, Hefei 230032, Anhui, Peoples R China
5.Peking Univ, Dept Psychiat, Affiliated Hosp 6, Beijing 100871, Peoples R China
6.Beijing Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China
7.Wuhan Univ, Dept Psychiat, Peoples Hosp, Wuhan 430072, Hubei, Peoples R China
8.China Med Univ, Affiliated Hosp 1, Dept Mental Hlth, Shenyang, Liaoning, Peoples R China
9.Seventh Hosp Hangzhou City, Dept Psychiat, Hangzhou, Zhejiang, Peoples R China
10.Zhejiang Univ, Sch Med, Dept Psychiat, Affiliated Hosp 2, Hangzhou 310003, Zhejiang, Peoples R China
11.Sixth Peoples Hosp Hebei Prov, Dept Psychiat, Baoding, Hebei, Peoples R China
12.Harbin Med Coll, Dept Psychiat, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
13.Shanxi Med Univ, Dept Psychiat, Hosp 1, Taiyuan, Shanxi, Peoples R China
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GB/T 7714
Zou, Yan-Feng,Wang, Yu,Liu, Ping,et al. Association of BDNF Val66Met Polymorphism with both baseline HRQOL scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2010,25(2):145-152.
APA Zou, Yan-Feng.,Wang, Yu.,Liu, Ping.,Feng, Xiao-Liang.,Wang, Bin-Yan.,...&Xu, Xi-Ping.(2010).Association of BDNF Val66Met Polymorphism with both baseline HRQOL scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine.HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,25(2),145-152.
MLA Zou, Yan-Feng,et al."Association of BDNF Val66Met Polymorphism with both baseline HRQOL scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine".HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL 25.2(2010):145-152.
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