北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
Association of BDNF Val66Met Polymorphism with both baseline HRQOL scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine
作者: Zou, Yan-Feng1; Wang, Yu2; Liu, Ping2; Feng, Xiao-Liang1,3; Wang, Bin-Yan2; Zang, Tong-Hua2; Yu, Xin4; Wei, Jing5; Liu, Zhong-Chun6; Liu, Ying7; Tao, Ming8; Li, Hui-Chun9; Li, Ke-Qing10; Hu, Jian11; Li, Ming12; Zhang, Ke-Rang13; Ye, Dong-Qing1; Xu, Xi-Ping2
关键词: health related quality of life ; major depressive disorder ; brain-derived neurotrophic factor ; polymorphism ; SSRIs
刊名: HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
发表日期: 2010-03-01
DOI: 10.1002/hup.1099
卷: 25, 期:2, 页:145-152
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Social Sciences
类目[WOS]: Clinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
关键词[WOS]: NEUROTROPHIC FACTOR BDNF ; QUALITY-OF-LIFE ; FACTOR GENE ; VAL(66)MET POLYMORPHISM ; TREATMENT-RESPONSE ; MEDICAL OUTCOMES ; BRAIN ; HEALTH ; SERUM ; DISORDERS
英文摘要:

Objective To explore the association of brain-derived neurotrophic-factor (BDNF) Val66Met polymorphism with both baseline health related quality of life (HRQOL) scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine.

Methods Patients with major depressive disorder (MDD) took fluoxetine (20 mg/day) for 6 weeks. The HRQOL was measured with the Medical Outcomes Study Short Form-36 (SF-36) at baseline and at 6th week. Patients were genotyped for Val66Met polymorphism of BDNF gene.

Results There was a significant association between social function (SF) and BDNF Val66Met polymorphism, and patients with Met/Met genotype had better SF (compared with Val/Val P = 0.004; compared with Val/Met P = 0.005). A significant association was found between improvement in SF and BDNF Val66Met polymorphism, and patients with Met/Met genotype had poorer improvement in SF (compared with Val/Val P = 0.010; compared with Val/Met P = 0.001). Similar association was found between improvement in mental component summary (MCS) and BDNF Val66Met polymorphism, and patients with Met/Met genotype had poorer improvement in MCS (compared with Val/Val P = 0.066; compared with Val/Met P = 0.006).

Conclusions These results indicate that there may be association between BDNF Val66Met polymorphism and both baseline HRQOL (SF) scores and improvement in HRQOL (SF, MCS) scores in Chinese major depressive patients treated with fluoxetine. Copyright (C) 2010 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000276078100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67982
Appears in Collections:北京大学精神卫生研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Suzhou Guangji Hosp, Dept Psychiat, Suzhou, Zhejiang, Peoples R China
2.Anhui Med Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Hefei 230032, Anhui, Peoples R China
3.Anhui Med Univ, Inst Biomed, Hefei 230032, Anhui, Peoples R China
4.Anhui Med Univ, Dept Basic Med Sci, Hefei 230032, Anhui, Peoples R China
5.Peking Univ, Dept Psychiat, Affiliated Hosp 6, Beijing 100871, Peoples R China
6.Beijing Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China
7.Wuhan Univ, Dept Psychiat, Peoples Hosp, Wuhan 430072, Hubei, Peoples R China
8.China Med Univ, Affiliated Hosp 1, Dept Mental Hlth, Shenyang, Liaoning, Peoples R China
9.Seventh Hosp Hangzhou City, Dept Psychiat, Hangzhou, Zhejiang, Peoples R China
10.Zhejiang Univ, Sch Med, Dept Psychiat, Affiliated Hosp 2, Hangzhou 310003, Zhejiang, Peoples R China
11.Sixth Peoples Hosp Hebei Prov, Dept Psychiat, Baoding, Hebei, Peoples R China
12.Harbin Med Coll, Dept Psychiat, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
13.Shanxi Med Univ, Dept Psychiat, Hosp 1, Taiyuan, Shanxi, Peoples R China

Recommended Citation:
Zou, Yan-Feng,Wang, Yu,Liu, Ping,et al. Association of BDNF Val66Met Polymorphism with both baseline HRQOL scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2010,25(2):145-152.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zou, Yan-Feng]'s Articles
[Wang, Yu]'s Articles
[Liu, Ping]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zou, Yan-Feng]‘s Articles
[Wang, Yu]‘s Articles
[Liu, Ping]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace