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学科主题: 临床医学
题名:
H2S generated by heart in rat and its effects on cardiac function
作者: Geng, B; Yang, JH; Qi, YF; Zhao, J; Pang, YZ; Du, JB; Tang, CS
关键词: hydrogen sulfide ; cystathionine beta-synthase ; cystathionine gamma-synthase ; cardiac function
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2004-01-09
DOI: 10.1016/j.bbrc.2003.11.130
卷: 313, 期:2, 页:362-368
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: HYDROGEN-SULFIDE ; NITRIC-OXIDE ; HYPERTENSION ; METABOLISM ; SYNTHASE ; CELLS
英文摘要:

Hydrogen sulfide (H2S), which was considered as a novel gasotransmitter, is produced endogenously from L-cysteine in mammalian brain and vessels, and might be a physiological function regulator to these organs. Here, we showed that mRNA for H2S producing enzyme, cystathionine gamma-lyase, was expressed in myocardial tissues and H2S could endogenously be produced in myocardial tissues. Negative inotropic effect of H2S was proved in present study in vitro and in vivo experiments, and the effect could partly be blocked by glibenclamide, a K-ATP channel blocker. An intravenous bolus injection of NaHS provoked a decrease in central venous pressure. The present findings suggested that H2S could be endogenously produced by heart tissues, as a physiological cardiac function regulator, mediated by K-ATP channel pathway. (C) 2003 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000187746100020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67994
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Cardiovasc Res Inst, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing, Peoples R China

Recommended Citation:
Geng, B,Yang, JH,Qi, YF,et al. H2S generated by heart in rat and its effects on cardiac function[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,313(2):362-368.
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