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An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia
Zhang, BY; Yuan, YB; Jia, YB; Yu, X; Xu, Q; Shen, YC; Shen, Y
关键词schizophrenia association study GLS GLUL GAD ABAT ALDH5A1
刊名EUROPEAN PSYCHIATRY
2005
DOI10.1016/j.eurpsy.2004.09.028
20期:1页:45-49
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]MESSENGER-RNA EXPRESSION ; PREFRONTAL CORTEX ; ACID DECARBOXYLASE ; NEURONS ; BRAIN
英文摘要

Dysfunctions of glutamatergic and GABAergic neurotransmission are two important hypotheses for the pathogensis of schizophrenia. Thus, genes in the pathway are candidates for schizophrenia susceptibility. Phosphate-activated glutaminase (GLS), glutamine synthetase (GLUL), glutamic acid decarboxylase (GAD), GABA transaminase (ABAT) and succinic semialdehyde dehydrogenase (ALDH5Al) are five primary enzymes in glutamate and GABA synthetic and degradative pathway. In order to investigate the possible involvement of these genes in the development of paranoid schizophrenia, we genotyped 80 paranoid schizophrenics front northern China and 108 matched controls by polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) methods or directly sequencing of PCR product. Seven SNPs were found to be polymorphic in the Population investigated. No significant differences in the genotype distributions or allele frequencies between patients and controls were found. Therefore, we conclude the polymorphisms studied in the five gene L do not play major roles in pathogenesis of paranoid schizophrenia in the population investigated. (C) 2004 Elsevier SAS. All rights reserved.

语种英语
WOS记录号WOS:000226712800007
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68000
专题北京大学精神卫生研究所
作者单位1.Natl Ctr Human Genome Res, Beijing 100176, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China
4.Peking Union Med Coll, Beijing 100005, Peoples R China
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Zhang, BY,Yuan, YB,Jia, YB,et al. An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia[J]. EUROPEAN PSYCHIATRY,2005,20(1):45-49.
APA Zhang, BY.,Yuan, YB.,Jia, YB.,Yu, X.,Xu, Q.,...&Shen, Y.(2005).An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia.EUROPEAN PSYCHIATRY,20(1),45-49.
MLA Zhang, BY,et al."An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia".EUROPEAN PSYCHIATRY 20.1(2005):45-49.
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