北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia
作者: Zhang, BY; Yuan, YB; Jia, YB; Yu, X; Xu, Q; Shen, YC; Shen, Y
关键词: schizophrenia ; association study ; GLS ; GLUL ; GAD ; ABAT ; ALDH5A1
刊名: EUROPEAN PSYCHIATRY
发表日期: 2005
DOI: 10.1016/j.eurpsy.2004.09.028
卷: 20, 期:1, 页:45-49
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: MESSENGER-RNA EXPRESSION ; PREFRONTAL CORTEX ; ACID DECARBOXYLASE ; NEURONS ; BRAIN
英文摘要:

Dysfunctions of glutamatergic and GABAergic neurotransmission are two important hypotheses for the pathogensis of schizophrenia. Thus, genes in the pathway are candidates for schizophrenia susceptibility. Phosphate-activated glutaminase (GLS), glutamine synthetase (GLUL), glutamic acid decarboxylase (GAD), GABA transaminase (ABAT) and succinic semialdehyde dehydrogenase (ALDH5Al) are five primary enzymes in glutamate and GABA synthetic and degradative pathway. In order to investigate the possible involvement of these genes in the development of paranoid schizophrenia, we genotyped 80 paranoid schizophrenics front northern China and 108 matched controls by polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) methods or directly sequencing of PCR product. Seven SNPs were found to be polymorphic in the Population investigated. No significant differences in the genotype distributions or allele frequencies between patients and controls were found. Therefore, we conclude the polymorphisms studied in the five gene L do not play major roles in pathogenesis of paranoid schizophrenia in the population investigated. (C) 2004 Elsevier SAS. All rights reserved.

语种: 英语
WOS记录号: WOS:000226712800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68000
Appears in Collections:北京大学精神卫生研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Natl Ctr Human Genome Res, Beijing 100176, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China
4.Peking Union Med Coll, Beijing 100005, Peoples R China

Recommended Citation:
Zhang, BY,Yuan, YB,Jia, YB,et al. An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia[J]. EUROPEAN PSYCHIATRY,2005,20(1):45-49.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, BY]'s Articles
[Yuan, YB]'s Articles
[Jia, YB]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, BY]‘s Articles
[Yuan, YB]‘s Articles
[Jia, YB]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace