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学科主题: 药学
题名:
A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells
作者: Peng, Zuo-fu1; Lan, Lin-xiang1; Zhao, Fang1; Li, Jing1; Tan, Qiang2; Yin, Han-wei3; Zeng, Hui-hui1
关键词: thioredoxin reductase (TrxR) ; novel TrxR inhibitor ; 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE) ; apoptosis
刊名: JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
发表日期: 2008
DOI: 10.1631/jzus.B071605
卷: 9, 期:1, 页:16-21
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: POSSIBLE INVOLVEMENT ; DIRECT ASSOCIATION ; EXPRESSION ; CANCER ; LEUKEMIA ; SENSITIVITY ; RESISTANCE ; CARCINOMA ; LINES
英文摘要:

Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE), a novel TrxR inhibitor, were investigated on human leukemia cell lines HL-60 and K562. BBSKE treatment induced cell growth inhibition and apoptosis in both cell lines. Apoptosis induced by BBSKE is through Bcl-2/Bax and caspase-3 pathways. Ehrlich′s ascites carcinoma-bearing mice were used to investigate the anti-tumor effect of BBSKE in vivo. Tumor-bearing mice treated with BBSKE showed an increase of life span with a comparable effect to cyclophosphamide (CTX). These results suggest a potential usage of BBSKE as a therapeutic agent against non-solid tumors.

语种: 英语
WOS记录号: WOS:000253218300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68005
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Coll Life Sci, Beijing 100075, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
3.Peking Univ First Hosp, Dept Geriatr Med, Beijing 100034, Peoples R China

Recommended Citation:
Peng, Zuo-fu,Lan, Lin-xiang,Zhao, Fang,et al. A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells[J]. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,2008,9(1):16-21.
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