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学科主题: 药学
题名:
Copper Powder-Catalyzed Regio- and Stereoselective Aminobromination of alpha,beta-Unsaturated Ketones with TsNH2 and NBS as Nitrogen and Halogen Sources
作者: Chen, Zhan-Guo1; Wei, Jun-Fa1; Li, Run-Tao2; Shi, Xian-Ying1; Zhao, Peng-Fei1
刊名: JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2009-02-06
DOI: 10.1021/jo8023768
卷: 74, 期:3, 页:1371-1373
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ELECTROPHILIC DIAMINATION ; CINNAMIC ESTERS ; ALKENES ; AMINOHALOGENATION ; OLEFINS ; COMBINATION ; COMPLEX
英文摘要:

The regio- and stereoselective aminobromination of alpha,beta-unsaturated ketones catalyzed by copper powder has been established with 4-TsNH2 and NBS as the nitrogen/bromine sources, respectively. This method provides an easy access for preparation of vicinal aminohalo derivatives in the presence of I mol % catalyst. Electron-rich alpha,beta-unsaturated ketones afforded the corresponding aminobrominated products in excellent yields (up to 99.8%), revealing that the addition has an electrophilic feature.

语种: 英语
所属项目编号: 20572066 ; 2008CXB009
项目资助者: National Foundation of Natural Science in China ; Innovation Foundation of Postgraduate Cultivation of Shaanxi Normal University
WOS记录号: WOS:000263004300058
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68008
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shaanxi Normal Univ, Sch Chem & Mat Sci, Xian 710062, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Chen, Zhan-Guo,Wei, Jun-Fa,Li, Run-Tao,et al. Copper Powder-Catalyzed Regio- and Stereoselective Aminobromination of alpha,beta-Unsaturated Ketones with TsNH2 and NBS as Nitrogen and Halogen Sources[J]. JOURNAL OF ORGANIC CHEMISTRY,2009,74(3):1371-1373.
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