IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题临床医学
Noncontrast Skeletal Muscle Oximetry
Zheng, Jie1; An, Hongyu2; Coggan, Andrew R.1; Zhang, Xiaodong3; Bashir, Adil1; Muccigrosso, David1; Peterson, Linda R.1; Gropler, Robert J.1
关键词cardiovascular magnetic resonance arterial spin labeling skeletal muscle oxygen consumption oxygen extraction fraction
刊名MAGNETIC RESONANCE IN MEDICINE
2014
DOI10.1002/mrm.24669
71期:1页:318-325
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
资助者Washington University Institute of Clinical and Translational Sciences, National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) ; Washington University Institute of Clinical and Translational Sciences, National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH)
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]NEAR-INFRARED SPECTROSCOPY ; PERIPHERAL ARTERIAL-DISEASE ; ENDURANCE-TRAINED MEN ; BLOOD-FLOW ; REACTIVE HYPEREMIA ; OXYGEN EXTRACTION ; IN-VIVO ; BIOMECHANICAL EFFICIENCY ; ENERGY-EXPENDITURE ; SIGNAL BEHAVIOR
英文摘要

PurposeThe objective of this study was to develop a new noncontrast method to directly quantify regional skeletal muscle oxygenation.

MethodsThe feasibility of the method was examined in five healthy volunteers using a 3 T clinical MRI scanner, at rest and during a sustained isometric contraction. The perfusion of skeletal muscle of the calf was measured using an arterial spin labeling method, whereas the oxygen extraction fraction of the muscle was measured using a susceptibility-based MRI technique.

ResultsIn all volunteers, the perfusion in soleus muscle increased significantly from 6.52.0 mL (100 g min)(-1) at rest to 47.9 +/- 7.7 mL (100 g min)(-1) during exercise (P<0.05). Although the corresponding oxygen extraction fraction did not change significantly, the rate of oxygen consumption increased from 0.43 +/- 0.13 to 4.2 +/- 1.5 mL (100 g min)(-1) (P<0.05). Similar results were observed in gastrocnemius muscle but with greater oxygen extraction fraction increase than the soleus muscle.

ConclusionThis is the first MR oximetry developed for quantification of regional skeletal muscle oxygenation. A broad range of medical conditions could benefit from these techniques, including cardiology, gerontology, kinesiology, and physical therapy. Magn Reson Med 71:318-325, 2014. (c) 2013 Wiley Periodicals, Inc.

语种英语
所属项目编号UL1 TR000448
资助者Washington University Institute of Clinical and Translational Sciences, National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) ; Washington University Institute of Clinical and Translational Sciences, National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH)
WOS记录号WOS:000328580300036
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68012
Collection北京大学第一临床医学院_放射治疗科
作者单位1.Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA
2.Univ N Carolina, Dept Radiol, Chapel Hill, NC USA
3.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Jie,An, Hongyu,Coggan, Andrew R.,et al. Noncontrast Skeletal Muscle Oximetry[J]. MAGNETIC RESONANCE IN MEDICINE,2014,71(1):318-325.
APA Zheng, Jie.,An, Hongyu.,Coggan, Andrew R..,Zhang, Xiaodong.,Bashir, Adil.,...&Gropler, Robert J..(2014).Noncontrast Skeletal Muscle Oximetry.MAGNETIC RESONANCE IN MEDICINE,71(1),318-325.
MLA Zheng, Jie,et al."Noncontrast Skeletal Muscle Oximetry".MAGNETIC RESONANCE IN MEDICINE 71.1(2014):318-325.
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