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学科主题: 药物依赖
题名:
Serum cortisol secretion during heroin abstinence is elevated only nocturnally
作者: Li, Su-xia1,2; Li, Jing2; Epstein, David H.3; Zhang, Xiang Yang4; Kosten, Thomas R.4; Lu, Lin1
关键词: circadian rhythm ; cortisol ; detoxification ; heroin abstainers
刊名: AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
发表日期: 2008
DOI: 10.1080/00952990802013664
卷: 34, 期:3, 页:321-328
收录类别: SSCI
文章类型: Article
WOS标题词: Social Sciences ; Science & Technology
类目[WOS]: Psychology, Clinical ; Substance Abuse
研究领域[WOS]: Psychology ; Substance Abuse
关键词[WOS]: CORTICOTROPIN-RELEASING HORMONE ; PITUITARY-ADRENAL RESPONSE ; CIGARETTE-SMOKING ; REWARD PATHWAYS ; DRUG-DEPENDENCE ; BETA-ENDORPHIN ; STRESS ; COCAINE ; WITHDRAWAL ; ADDICTS
英文摘要:

Several studies indicate abnormalities in the hypothalamic-pituitary-adrenal axis (HPA) during acute opiate withdrawal, but protracted withdrawal has gotten less study. The current study further characterized the 24-hour time course of plasma cortisol levels in heroin-dependent individuals who were abstinent for 10-15 days, which is beyond the 5 days of acute withdrawal, compared to demographically matched healthy controls using samples collected every 3 hours over 24 hours and assessed with radioimmunoassay (RIA). The abstinent heroin-dependent participants had significantly higher plasma cortisol levels nocturnally suggesting a loss of diurnal variation in these heroin subjects.

语种: 英语
WOS记录号: WOS:000255221800008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68018
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Sichuan Univ, W China Hosp, Inst Mental Hlth, Chengdu 610064, Peoples R China
3.NIDA, Intramural Res Program, NIH, Baltimore, MD USA
4.Baylor Coll Med, Div Alcohol & Addict Disorders, Houston, TX 77030 USA

Recommended Citation:
Li, Su-xia,Li, Jing,Epstein, David H.,et al. Serum cortisol secretion during heroin abstinence is elevated only nocturnally[J]. AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,2008,34(3):321-328.
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