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学科主题: 公共卫生
题名:
Improvements in quality of life associated with biphasic insulin aspart 30 in type 2 diabetes patients in China: results from the A(1)chieve (R) observational study
作者: Yang, Wenying1; Zhuang, Xiaoming2; Li, Yukun3; Wang, Qing4; Bian, Rongwen5; Shen, Jianguo6; Hammerby, Eva7; Yang, Li8
关键词: Quality of life ; Biphasic insulin aspart 30 ; Type 2 diabetes ; Chinese setting ; Observational ; EQ-5D
刊名: HEALTH AND QUALITY OF LIFE OUTCOMES
发表日期: 2014-11-26
DOI: 10.1186/s12955-014-0137-9
卷: 12
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Health Care Sciences & Services ; Health Policy & Services
研究领域[WOS]: Health Care Sciences & Services
关键词[WOS]: TREATMENT SATISFACTION ; BASAL INSULIN ; THERAPY ; HEALTH ; HYPOGLYCEMIA ; GLARGINE ; IMPACT ; INTERVENTIONS ; ANALOGS ; ADULTS
英文摘要:

Background: Based on the 24-week, prospective, non-interventional, observational study, A(1)chieve (R), we investigated how health-related quality of life (HRQoL) changed, and the predictors of such changes, in Chinese people with type 2 diabetes mellitus (T2DM) after starting with, or switching to, biphasic insulin aspart 30 (BIAsp 30).

Methods: In total, 8,578 people with T2DM starting treatment with, or switching to, BIAsp 30 were recruited from 130 urban hospitals in China. HRQoL was assessed at baseline and 24 weeks using the EuroQol-5 dimensions (EQ-5D) questionnaire. Descriptive statistics, paired t-test, and chi-square test were conducted and the linear ordinary least squares regression model was used to determine predictors for changes in EQ-5D score.

Results: Haemoglobin A(1c) (HbA(1c)) decreased from 9.5% to 7.0% after 24 weeks. The reported HRQoL measured by the EQ-5D visual analogue scale score increased by 6.2 (p < 0.001) from 75.8 to 82.0, and EQ-5D index score increased by 0.018 (p < 0.001) from 0.875 to 0.893 for the cohort over 24 weeks. The percentage of patients reporting no problems in the mobility, pain/discomfort, and anxiety/depression dimensions of EQ-5D increased significantly (p < 0.001) from 88.4% to 91.4%, 77.3% to 82.8%, and 74.2% to 77.1%, respectively. Patients with higher HbA1c levels at baseline, major hypoglycaemia or micro-complications exhibited significantly larger changes in EQ-5D scores than those with lower baseline HbA1c levels, without major hypoglycaemia or micro-complications after controlling for demographics and other baseline characteristics.

Conclusions: BIAsp 30 treatment was associated with improved glycaemic control and HRQoL in T2DM patients in China. Patients with worse health conditions were more likely to experience larger improvements in HRQoL than those with better health conditions.

语种: 英语
所属项目编号: 71273016 ; 10YJC630332
项目资助者: National Science Foundation of China ; Young Foundation of Ministry of Education, Humanities and Social Science Research Projects ; Novo Nordisk (China) Pharmaceuticals Co., Ltd.
WOS记录号: WOS:000347424300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68024
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.China Japan Friendship Hosp, Beijing, Peoples R China
2.Capital Med Univ, Fu Xing Hosp, Beijing, Peoples R China
3.Hebei Med Univ, Hosp 3, Shijiazhuang, Hebei, Peoples R China
4.Jiangsu Prov Official Hosp, Nanjing, Jiangsu, Peoples R China
5.Novo Nordisk AS, Copenhagen, Denmark
6.Jilin Univ, China Japan Union Hosp, Dept Endocrinol, Changchun 130023, Peoples R China
7.Zhejiang Univ, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
8.Peking Univ, Sch Publ Hlth, Dept Hlth Policy & Management, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Wenying,Zhuang, Xiaoming,Li, Yukun,et al. Improvements in quality of life associated with biphasic insulin aspart 30 in type 2 diabetes patients in China: results from the A(1)chieve (R) observational study[J]. HEALTH AND QUALITY OF LIFE OUTCOMES,2014,12.
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