学科主题临床医学
Diarrhea during the Conditioning Regimen Is Correlated with the Occurrence of Severe Acute Graft-versus-Host Disease through Systemic Release of Inflammatory Cytokines
Liu, Daihong; Yan, Chenhua; Xu, Lanping; Wang, Yu; Han, Wei; Zhang, Xiaohui; Liu, Kaiyan; Huang, Xiaojun
关键词Acute graft-versus-host disease Allogeneic hematopoietic stem cell transplantation Diarrhea related to the conditioning regimen Tumor necrosis factor-alpha (TNF-alpha) Interleukin-6 (IL-6)
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2010-11-01
DOI10.1016/j.bbmt.2010.05.001
16期:11页:1567-1575
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]NECROSIS-FACTOR-ALPHA ; BONE-MARROW-TRANSPLANTATION ; STEM-CELL TRANSPLANTATION ; PLASMA CYTOKINES ; COMPLICATIONS ; MUCOSITIS
英文摘要

Graft-versus-host disease (GVHD) is a major obstacle to the success of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although many indicators have been used to predict GVHD, the prediction of GVHD remains very difficult. Determining how to predict the occurrence of acute GVHD (aGVHD) as exactly as possible has been a huge challenge so far. Systemic release of inflammatory cytokines during the conditioning regimen and early-phase post-HSCT plays a crucial role in the generation of aGVHD; additionally, the conditioning regimen causes the damage to the intestinal tract. Diarrhea is a common symptom of intestinal tract damage during the conditioning regimen. We therefore performed a prospective study to investigate the relationship between diarrhea related to the conditioning regimen, systemic release of inflammatory cytokines during the conditioning regimen and the early-phase post-HSCT, and the development of aGVHD. This study demonstrated that duration of diarrhea was >5.5 days, with a maximal volume >8.72 mL/kg and a mean volume of diarrhea for days -3 to 0 >7.94 mL/kg were risk factors of grade II to IV aGVHD. Diarrhea with any 1 risk factor was defined as severe diarrhea. Furthermore, this study first confirmed that the correlation between diarrhea and aGVHD was related to the serum levels of tumor necrosis factor (INF)-alpha and interleuk in (IL)-6 during the conditioning regimen and during the early phase after transplantation. Our study demonstrated that diarrhea related to the conditioning regimen could be used as a marker for the prediction of aGVHD and further explain the possible mechanism underlying the linkage described here. Therefore, for the patients with severe diarrhea related to the conditioning regimen, low-dose glucocorticoid may be used to reduce the levels of inflammatory cytokine release by a damaged intestinal tract, and possibly further reduce the occurrence of aGVHD. For these patients, prophylaxis of aGVHD may be need to be adjusted individually.

语种英语
WOS记录号WOS:000283830800008
项目编号2006-1010 ; 30725038 ; IRT 0702
资助机构Scientific Research Fund for Capital Medicine Development ; National Outstanding Young Scientist&prime ; s Foundation of China ; Program for Innovative Research Team in University
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68026
专题医学人文研究院/公共教学部_哲学与社会科学系
北京大学第二临床医学院_血液科
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Liu, Daihong,Yan, Chenhua,Xu, Lanping,et al. Diarrhea during the Conditioning Regimen Is Correlated with the Occurrence of Severe Acute Graft-versus-Host Disease through Systemic Release of Inflammatory Cytokines[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2010,16(11):1567-1575.
APA Liu, Daihong.,Yan, Chenhua.,Xu, Lanping.,Wang, Yu.,Han, Wei.,...&Huang, Xiaojun.(2010).Diarrhea during the Conditioning Regimen Is Correlated with the Occurrence of Severe Acute Graft-versus-Host Disease through Systemic Release of Inflammatory Cytokines.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,16(11),1567-1575.
MLA Liu, Daihong,et al."Diarrhea during the Conditioning Regimen Is Correlated with the Occurrence of Severe Acute Graft-versus-Host Disease through Systemic Release of Inflammatory Cytokines".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 16.11(2010):1567-1575.
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