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学科主题基础医学
Interaction of HIV-1 fusion peptide and its mutant with lipid membrane
Qiu, Y; Sha, YL; Huang, LX; Lin, KC; Nie, SQ
关键词human immunodeficiency virus type 1 fusion peptide lipid membrane
刊名CHINESE SCIENCE BULLETIN
2000-05-01
45期:9页:819-825
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]IMMUNODEFICIENCY-VIRUS TYPE-1 ; ENVELOPE GLYCOPROTEIN ; GP41 ; DOMAIN
英文摘要

HIVWT and HIVV2E represent the 23 amino acids fusion peptide of HIV-1 gp41 N terminus and its position 2 mutant (Val-->Glu). We have studied the structure-function relationship of HIVWT and HIVV2E when they interact with acidic and neutral lipid membranes. The results show that HIVWT and HIVV2E have the same conformational characteristics and tendencies of conformational transition but definitely different functions: HIVWT destabilizes membrane and induces fusion by adopting predominant alpha-helix conformation when interacting with acidic POPG membrane, its phenylalanine residues can penetrate into the hydrophobic core of POPG bilayer; HIVV2E also adopts predominant alpha-helix when interacting with POPG membrane, but it cannot destabilize POPG membrane and induce fusion, the phenylalanine residues of it are located near the surface of POPG bilayer. HIVWT and HIVV2E both adopt predominant beta-sheet conformation to interact with neutral POPC membrane, and cannot destabilize POPC membrane and induce fusion, the position of phenylalanine residues of both HIVWT and HIVV2E are close to the surface of POPC bilayer. These results demonstrate that the N terminal hydrophobicity of fusion peptide and the secondary structure when interacting with lipid membrane play important roles for fusion peptide exerting its function.

语种英语
WOS记录号WOS:000087504300011
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68031
专题北京大学基础医学院_生物物理学系
作者单位1.Beijing Med Univ, Dept Biophys, Beijing 100083, Peoples R China
2.Peking Univ, Inst Phys Chem, Beijing 100871, Peoples R China
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GB/T 7714
Qiu, Y,Sha, YL,Huang, LX,et al. Interaction of HIV-1 fusion peptide and its mutant with lipid membrane[J]. CHINESE SCIENCE BULLETIN,2000,45(9):819-825.
APA Qiu, Y,Sha, YL,Huang, LX,Lin, KC,&Nie, SQ.(2000).Interaction of HIV-1 fusion peptide and its mutant with lipid membrane.CHINESE SCIENCE BULLETIN,45(9),819-825.
MLA Qiu, Y,et al."Interaction of HIV-1 fusion peptide and its mutant with lipid membrane".CHINESE SCIENCE BULLETIN 45.9(2000):819-825.
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