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学科主题: 基础医学
题名:
Interaction of HIV-1 fusion peptide and its mutant with lipid membrane
作者: Qiu, Y; Sha, YL; Huang, LX; Lin, KC; Nie, SQ
关键词: human immunodeficiency virus type 1 ; fusion peptide ; lipid membrane
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2000-05-01
卷: 45, 期:9, 页:819-825
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: IMMUNODEFICIENCY-VIRUS TYPE-1 ; ENVELOPE GLYCOPROTEIN ; GP41 ; DOMAIN
英文摘要:

HIVWT and HIVV2E represent the 23 amino acids fusion peptide of HIV-1 gp41 N terminus and its position 2 mutant (Val-->Glu). We have studied the structure-function relationship of HIVWT and HIVV2E when they interact with acidic and neutral lipid membranes. The results show that HIVWT and HIVV2E have the same conformational characteristics and tendencies of conformational transition but definitely different functions: HIVWT destabilizes membrane and induces fusion by adopting predominant alpha-helix conformation when interacting with acidic POPG membrane, its phenylalanine residues can penetrate into the hydrophobic core of POPG bilayer; HIVV2E also adopts predominant alpha-helix when interacting with POPG membrane, but it cannot destabilize POPG membrane and induce fusion, the phenylalanine residues of it are located near the surface of POPG bilayer. HIVWT and HIVV2E both adopt predominant beta-sheet conformation to interact with neutral POPC membrane, and cannot destabilize POPC membrane and induce fusion, the position of phenylalanine residues of both HIVWT and HIVV2E are close to the surface of POPC bilayer. These results demonstrate that the N terminal hydrophobicity of fusion peptide and the secondary structure when interacting with lipid membrane play important roles for fusion peptide exerting its function.

语种: 英语
WOS记录号: WOS:000087504300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68031
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Beijing Med Univ, Dept Biophys, Beijing 100083, Peoples R China
2.Peking Univ, Inst Phys Chem, Beijing 100871, Peoples R China

Recommended Citation:
Qiu, Y,Sha, YL,Huang, LX,et al. Interaction of HIV-1 fusion peptide and its mutant with lipid membrane[J]. CHINESE SCIENCE BULLETIN,2000,45(9):819-825.
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