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学科主题临床医学
Melatonin Attenuates Isoflurane-Induced Acute Memory Impairments in Aged Rats
Liu, Yajie1; Ni, Cheng1; Tang, Yi1; Tian, Xiaosheng2,3,4; Zhou, Yang1; Qian, Min1; Li, Zhengqian1; Chui, Dehua2,3,4; Guo, Xiangyang1
刊名BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
2013-10-01
DOI10.1111/bcpt.12079
113期:4页:215-220
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]POSTOPERATIVE COGNITIVE DYSFUNCTION ; NITROUS OXIDE ANESTHESIA ; ALZHEIMERS-DISEASE ; RECEPTOR EXPRESSION ; ELDERLY-PATIENTS ; DELIRIUM ; SURGERY ; BRAIN ; ACQUISITION ; SECRETION
英文摘要

Melatonin is an endogenous hormone with neuroprotective effects. Melatonin levels in elderly patients are reduced after surgeries that require anaesthesia. Whether reduced melatonin levels are important for postoperative cognitive dysfunction (POCD) remains unclear. Here, we investigated the effects of melatonin on cognitive dysfunctions induced by isoflurane and mechanisms underlying these effects. Seventy-two 20-month-old Sprague-Dawley rats were randomly divided into six groups (n=12). These groups included M1 and M10 groups that received intraperitoneal melatonin at 1mg/kg or 10mg/kg, respectively, and an ISO group that received 4hr of inhaled 2% isoflurane. They also included M1+ISO and M10+ISO groups that received 1mg/kg or 10mg/kg of melatonin plus 4hr of inhaled 2% isoflurane, respectively, and a control group that received an equal volume of saline. Injections were administered daily for 14 consecutive days. Memory was assessed in the Morris water maze. Plasma and hippocampi were harvested to determine melatonin concentrations and MT1/MT2 receptor expression. Rats treated only with isoflurane showed significantly longer latencies in Morris water maze test trials compared with the control group, with shorter time in the probe trial (p<0.05). Although plasma melatonin levels and MT2 expression in the hippocampus were significantly decreased, MT1 expression was higher in the isoflurane group than in the control group (p<0.001). However, these parameters did not significantly vary in animals administered melatonin compared with controls. Isoflurane may induce cognitive dysfunction by influencing melatonin and MT1/MT2 levels. Melatonin can improve cognitive dysfunction by normalizing plasma melatonin and its receptor levels.

语种英语
WOS记录号WOS:000324297300001
项目编号30972835 ; 2012CB911004
资助机构National Natural Science Foundation of China ; NHTR of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68036
专题北京大学第三临床医学院_麻醉科
北京大学口腔医学院_第一门诊部
作者单位1.Peking Univ Third Hosp, Dept Anesthesiol, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Key Lab Neurosci,Minist Educ, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Publ Hlth, Beijing 100191, Peoples R China
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Liu, Yajie,Ni, Cheng,Tang, Yi,et al. Melatonin Attenuates Isoflurane-Induced Acute Memory Impairments in Aged Rats[J]. BASIC &amp; CLINICAL PHARMACOLOGY &amp; TOXICOLOGY,2013,113(4):215-220.
APA Liu, Yajie.,Ni, Cheng.,Tang, Yi.,Tian, Xiaosheng.,Zhou, Yang.,...&Guo, Xiangyang.(2013).Melatonin Attenuates Isoflurane-Induced Acute Memory Impairments in Aged Rats.BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,113(4),215-220.
MLA Liu, Yajie,et al."Melatonin Attenuates Isoflurane-Induced Acute Memory Impairments in Aged Rats".BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 113.4(2013):215-220.
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