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学科主题: 临床医学
题名:
Melatonin Attenuates Isoflurane-Induced Acute Memory Impairments in Aged Rats
作者: Liu, Yajie1; Ni, Cheng1; Tang, Yi1; Tian, Xiaosheng2,3,4; Zhou, Yang1; Qian, Min1; Li, Zhengqian1; Chui, Dehua2,3,4; Guo, Xiangyang1
刊名: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
发表日期: 2013-10-01
DOI: 10.1111/bcpt.12079
卷: 113, 期:4, 页:215-220
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
关键词[WOS]: POSTOPERATIVE COGNITIVE DYSFUNCTION ; NITROUS OXIDE ANESTHESIA ; ALZHEIMERS-DISEASE ; RECEPTOR EXPRESSION ; ELDERLY-PATIENTS ; DELIRIUM ; SURGERY ; BRAIN ; ACQUISITION ; SECRETION
英文摘要:

Melatonin is an endogenous hormone with neuroprotective effects. Melatonin levels in elderly patients are reduced after surgeries that require anaesthesia. Whether reduced melatonin levels are important for postoperative cognitive dysfunction (POCD) remains unclear. Here, we investigated the effects of melatonin on cognitive dysfunctions induced by isoflurane and mechanisms underlying these effects. Seventy-two 20-month-old Sprague-Dawley rats were randomly divided into six groups (n=12). These groups included M1 and M10 groups that received intraperitoneal melatonin at 1mg/kg or 10mg/kg, respectively, and an ISO group that received 4hr of inhaled 2% isoflurane. They also included M1+ISO and M10+ISO groups that received 1mg/kg or 10mg/kg of melatonin plus 4hr of inhaled 2% isoflurane, respectively, and a control group that received an equal volume of saline. Injections were administered daily for 14 consecutive days. Memory was assessed in the Morris water maze. Plasma and hippocampi were harvested to determine melatonin concentrations and MT1/MT2 receptor expression. Rats treated only with isoflurane showed significantly longer latencies in Morris water maze test trials compared with the control group, with shorter time in the probe trial (p<0.05). Although plasma melatonin levels and MT2 expression in the hippocampus were significantly decreased, MT1 expression was higher in the isoflurane group than in the control group (p<0.001). However, these parameters did not significantly vary in animals administered melatonin compared with controls. Isoflurane may induce cognitive dysfunction by influencing melatonin and MT1/MT2 levels. Melatonin can improve cognitive dysfunction by normalizing plasma melatonin and its receptor levels.

语种: 英语
所属项目编号: 30972835 ; 2012CB911004
项目资助者: National Natural Science Foundation of China ; NHTR of China
WOS记录号: WOS:000324297300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68036
Appears in Collections:北京大学第三临床医学院_麻醉科_期刊论文

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作者单位: 1.Peking Univ Third Hosp, Dept Anesthesiol, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Key Lab Neurosci,Minist Educ, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Yajie,Ni, Cheng,Tang, Yi,et al. Melatonin Attenuates Isoflurane-Induced Acute Memory Impairments in Aged Rats[J]. BASIC &amp; CLINICAL PHARMACOLOGY &amp; TOXICOLOGY,2013,113(4):215-220.
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