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学科主题: 临床医学
题名:
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension
作者: Lu, Xiangfeng1,3; Wang, Laiyuan1,5; Lin, Xu6,7; Huang, Jianfeng2,3; Gu, C. Charles1,8; He, Meian9; Shen, Hongbing10,11,12; He, Jiang13; Zhu, Jingwen6,7; Li, Huaixing6,7; Hixson, James E.14; Wu, Tangchun9; Dai, Juncheng10,11,12; Lu, Ling6,7; Shen, Chong10,11; Chen, Shufeng1,3; He, Lin15; Mo, Zengnan16,17; Hao, Yongchen1,3; Mo, Xingbo1,3; Yang, Xueli1,3; Li, Jianxin1,3; Cao, Jie1,3; Chen, Jichun1,3; Fan, Zhongjie18; Li, Ying1,3; Zhao, Liancheng1,3; Li, Hongfan5; Lu, Fanghong19; Yao, Cailiang11; Yu, Lin20; Xu, Lihua21; Mu, Jianjun22; Wu, Xianping23; Deng, Ying23; Hu, Dongsheng24,25; Zhang, Weidong24; Ji, Xu26; Guo, Dongshuang27; Guo, Zhirong28; Zhou, Zhengyuan29; Yang, Zili30; Wang, Renping31; Yang, Jun32; Zhou, Xiaoyang33; Yan, Weili34; Sun, Ningling35; Gao, Pingjin36; Gu, Dongfeng1,3
刊名: HUMAN MOLECULAR GENETICS
发表日期: 2015-02-01
DOI: 10.1093/hmg/ddu478
卷: 24, 期:3, 页:865-874
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]: GENE-CENTRIC ARRAY ; METABOLIC SYNDROME ; PREVALENCE ; MUTATIONS ; METAANALYSIS ; EXPRESSION ; AWARENESS ; GENOTYPES ; VARIANTS ; ARTERIES
英文摘要:

Hypertension is a common disorder and the leading risk factor for cardiovascular disease and premature deaths worldwide. Genome-wide association studies (GWASs) in the European population have identified multiple chromosomal regions associated with blood pressure, and the identified loci altogether explain only a small fraction of the variance for blood pressure. The differences in environmental exposures and genetic background between Chinese and European populations might suggest potential different pathways of blood pressure regulation. To identify novel genetic variants affecting blood pressure variation, we conducted a meta-analysis of GWASs of blood pressure and hypertension in 11 816 subjects followed by replication studies including 69 146 additional individuals. We identified genome-wide significant (P < 5.0 x 10(-8)) associations with blood pressure, which included variants at three new loci (CACNA1D, CYP21A2, and MED13L) and a newly discovered variant near SLC4A7. We also replicated 14 previously reported loci, 8 (CASZ1, MOV10, FGF5, CYP17A1, SOX6, ATP2B1, ALDH2, and JAG1) at genome-wide significance, and 6 (FIGN, ULK4, GUCY1A3, HFE, TBX3-TBX5, and TBX3) at a suggestive level of P = 1.81 x 10(-3) to 5.16 x 10(-8). These findings provide new mechanistic insights into the regulation of blood pressure and potential targets for treatments.

语种: 英语
所属项目编号: 2012AA02A516 ; 2009AA022703 ; 2006AA02A406 ; 2011CB503901 ; 30930047 ; 2011BAI11B03 ; 2011BAI09B03 ; H020220030130 ; U01HL072507 ; R01HL 087263 ; R01HL090682 ; 2009AA022704 ; 2012CB524900 ; 30930081 ; 81170734 ; 81021002 ; 81273165 ; 81172751 ; KSCX2-EW-R-10 ; SIBS2008006 ; 12GWZX0702 ; 2009AA022705 ; BK2011776 ; 2011CB503806
项目资助者: High-Tech Research and Development Program of China (863 Plan) ; National Basic Research Program of China (973 Plan) from the Ministry of Science and Technology of China ; National Science Foundation of China ; Ministry of Science and Technology of China ; Biomedical Project from the Council of Science and Technology, Beijing ; National Heart, Lung, and Blood Institute, National Institutes of Health (Bethesda, Maryland, USA) ; National High Technology Research and Development Program (863 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Key Discipline of Shanghai Public Health-Food and Nutritional Sciences ; China National High-Tech Research and Development Program Grant ; Natural Science Foundation of Jiangsu Province ; National Basic Research Program Grant ; Program of Introducing Talents of Discipline to Universities ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000350137900021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68039
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Natl Human Genome Ctr Beijing, Beijing 100176, Peoples R China
2.Chinese Acad Med Sci, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China
3.Chinese Acad Med Sci, Div Hypertens, Beijing 100037, Peoples R China
4.Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, Beijing 100037, Peoples R China
5.Peking Union Med Coll, Beijing 100037, Peoples R China
6.Chinese Acad Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
7.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China
8.Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA
9.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, Wuhan 430030, Hubei, Peoples R China
10.Nanjing Med Univ, Minist Educ, Key Lab Modern Toxicol, Dept Epidemiol & Biostat, Nanjing 211166, Jiangsu, Peoples R China
11.Nanjing Med Univ, Sch Publ Hlth, Nanjing 211166, Jiangsu, Peoples R China
12.Nanjing Med Univ, Clin Epidemiol Sect, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Ctr Canc, Nanjing 210029, Jiangsu, Peoples R China
13.Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA 70112 USA
14.Univ Texas Sch Publ Hlth, Dept Epidemiol, Houston, TX 77025 USA
15.Shanghai Jiao Tong Univ, Bio X Inst, Minist Educ, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai 200030, Peoples R China
16.Guangxi Med Univ, Ctr Genom & Personalized Med, Med Sci Res Ctr, Sch Publ Hlth, Nanning 530021, Guangxi, Peoples R China
17.Guangxi Med Univ, Dept Occupat Hlth & Environm Hlth, Sch Publ Hlth, Nanning 530021, Guangxi, Peoples R China
18.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Cardiol, Beijing 100037, Peoples R China
19.Shandong Acad Med Sci, Inst Basic Med, Cardiocerebrovasc Control & Res Ctr, Jinan 250062, Shandong, Peoples R China
20.Fujian Prov Peoples Hosp, Dept Cardiol, Fuzhou 350004, Fujian, Peoples R China
21.Beihua Univ, Affiliated Hosp, Dept Cardiol, Fengman 132011, Jilin, Peoples R China
22.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Cardiol, Coll Med, Xian 710061, Shannxi, Peoples R China
23.Sichuan Ctr Dis Control & Prevent, Ctr Chron & Noncommunicable Dis Control & Prevent, Chengdu 610041, Sichuan, Peoples R China
24.Zhengzhou Univ, Sch Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
25.Shenzhen Univ, Sch Med, Shenzhen 518000, Guangdong, Peoples R China
26.Xinle Red Cross Hosp, Dept Internal Med, Xinle 050700, Hebei, Peoples R China
27.Yuxian Renmin Hosp, Dept Internal Med, Yuxian 045100, Shanxi, Peoples R China
28.Soochow Univ, Coll Med, Sch Publ Hlth, Dept Epidemiol, Suzhou 215123, Jiangsu, Peoples R China
29.Changshu Ctr Dis Control & Prevent, Changshu 215501, Jiangsu, Peoples R China
30.Nantong Ctr Dis Control & Prevent, Nantong 226007, Jiangsu, Peoples R China
31.Shijiazhuang Greatwall Hosp, Dept Internal Med, Shijiazhuang 052260, Hebei, Peoples R China
32.Hanzhong Peoples Hosp, Dept Cardiol, Hanzhong 723000, Shannxi, Peoples R China
33.Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan 430060, Hubei, Peoples R China
34.Fudan Univ, Dept Clin Epidemiol, Childrens Hosp, Shanghai 200062, Peoples R China
35.Peking Univ, Peoples Hosp, Dept Heart Ctr, Beijing 100044, Peoples R China
36.Shanghai Jiao Tong Univ, Sch Med, State Key Lab Med Genet, Shanghai Rui Jin Hosp, Shanghai 200025, Peoples R China

Recommended Citation:
Lu, Xiangfeng,Wang, Laiyuan,Lin, Xu,et al. Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension[J]. HUMAN MOLECULAR GENETICS,2015,24(3):865-874.
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