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学科主题: 基础医学
题名:
Phospholipid transfer protein (PLTP) deficiency impaired blood-brain barrier integrity by increasing cerebrovascular oxidative stress
作者: Zhou, Ting1,2,3; He, Qihua4; Tong, Yawei1,2,3; Zhan, Rui1,2,3; Xu, Feng5; Fan, Dongsheng6; Guo, Xiangyang6; Han, Hongbin6; Qin, Shucun7; Chui, Dehua1,2,3,6
关键词: Phospholipid transfer protein ; Blood-brain barrier ; Tight junction ; Oxidative stress
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2014-03-07
DOI: 10.1016/j.bbrc.2014.01.194
卷: 445, 期:2, 页:352-356
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: ALPHA-TOCOPHEROL ; IN-VITRO ; DYSFUNCTION ; MICE ; ACCUMULATION ; LIPOPROTEINS ; PERMEABILITY ; CELLS
英文摘要:

Phospholipid transfer protein (PLTP) regulates lipid metabolism and plays an important role in oxidative stress. PLTP is highly expressed in blood-brain barrier (BBB), but the role of PLTP in BBB integrity is not clear. In this study, BBB permeability was detected with in vivo multiphoton imaging and Evans blue assay. We found that PLTP deficient mice exhibited increased BBB permeability, as well as decreased expression of tight junction proteins occludin, zona occludens-1 (ZO-1) and claudin-5 in brain vessels. Cerebrovascular oxidative stress increased in PLTP deficient mice, including increased levels of reactive oxygen species (ROS) and lipid peroxidation marker 4-hydroxy-2-nonenal (HNE) and reduced superoxide dismutase (SOD) activity. Dietary supplementation of antioxidant vitamin E increased BBB integrity and tight junction proteins expression via reducing cerebrovascular oxidative stress. These findings indicated an essential role of PLTP in maintaining BBB integrity, possibly through its ability to transfer vitamin E, and modulate cerebrovascular oxidative stress. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2012CB911000 ; 2012CB911004 ; 81171015
项目资助者: National High Technology Research and Development Program of China ; National Natural Science Foundation of China (NSFC)
WOS记录号: WOS:000333228700015
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68042
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
2.Peking Univ, Dept Neurobiol, Key Lab Neurosci, Minist Educ, Beijing 100871, Peoples R China
3.Peking Univ Third Hosp, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Publ Hlth, Beijing 100871, Peoples R China
5.Peking Univ, Ctr Med & Hlth Anal, Beijing 100871, Peoples R China
6.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100871, Peoples R China
7.Taishan Med Univ, Key Lab Atherosclerosis Univ Shandong, Tai An, Shandong, Peoples R China

Recommended Citation:
Zhou, Ting,He, Qihua,Tong, Yawei,et al. Phospholipid transfer protein (PLTP) deficiency impaired blood-brain barrier integrity by increasing cerebrovascular oxidative stress[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,445(2):352-356.
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