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学科主题: 临床医学
题名:
Influenza virus haemagglutinin-derived peptides inhibit T-cell activation induced by HLA-DR4/1 specific peptides in rheumatoid arthritis
作者: Li, X; Li, R; Li, Z
关键词: altered peptide ligands ; T-cell responses ; type II collagen ; influenza virus haemagglutinin ; rheumatoid arthritis
刊名: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
发表日期: 2006-03-01
卷: 24, 期:2, 页:148-154
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: CLASS-II COMPLEXES ; HUMAN COLLAGEN-II ; CYTOKINE PRODUCTION ; TH2 DEVIATION ; IN-VIVO ; LIGAND ; RESPONSES ; RECEPTOR ; SUSCEPTIBILITY ; EXPRESSION
英文摘要:

Objective. To investigate whether influenza virus haemagglutinin (HA)-derived altered peptide ligands (APLs) could abrogate T-cell responses to wild type HA308-317 or type II collagen (CII) 263-272 peptides and explore the potential inhibitory effects of the altered HA308-317 peptides on T-cell activation in rheumatoid arthritis (RA).

Methods. Altered HA308-317 peptides containing substitutions of T-cell receptor (TCR)-contact residues were synthesized. Peripheral blood mononuclear cells (PBMC) were obtained from 27 HLA-DR4/1-positive RA patients. Impact of the altered HA308-317 peptides on T-cell responses and the inhibitory effects on T-cell activation were determined by using PBMC from RA.

Results. The results showed that the altered HA308-317 peptides could bind to HLA-DR4/1 on cell surface and had no effects on T-cell proliferation and CD25 expression. Moreover all the altered HA308-317 peptides inhibited T-cell proliferative responses to wild type HA308-317 or CII263-272. In addition, Th1 type cytokine profile was found when PBMC were cultured with wild type HA308-317 or CII263-272, but not the altered HA 308-317 peptides.

Conclusions. It is suggested that altered HA308-317 peptides bind to the RA-associated HLA-DR4/1 with no stimulating effects on T cells and might be potentially important in inhibition of T-cell activation in RA.

语种: 英语
WOS记录号: WOS:000237907000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68046
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Beijing Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China
2.Dalian Univ Technol, Sch Med, Dept Immunol, Dalian, Peoples R China

Recommended Citation:
Li, X,Li, R,Li, Z. Influenza virus haemagglutinin-derived peptides inhibit T-cell activation induced by HLA-DR4/1 specific peptides in rheumatoid arthritis[J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,2006,24(2):148-154.
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