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学科主题: 精神卫生
题名:
Neurobehavioral effects of HIV-1 infection in china and the united states: A pilot study
作者: Cysique, Lucette A.; Jin, Hua; Franklin, Donald R., Jr.; Morgan, Erin E.; Shi, Chuan; Yu, Xin; Wu, Zunyou; Taylor, Michael J.; Marcotte, Thomas D.; Letendre, Scott; Ake, Christopher; Grant, Igor; Heaton, Robert K.; HNRC Grp
关键词: HIV/AIDS ; neuropsychological functioning ; cognition ; China ; cross-cultural assessment ; everyday functioning
刊名: JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
发表日期: 2007-09-01
DOI: 10.1017/S1355617707071007
卷: 13, 期:5, 页:781-790
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Social Sciences
类目[WOS]: Clinical Neurology ; Neurosciences ; Psychiatry ; Psychology
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry ; Psychology
关键词[WOS]: IMMUNODEFICIENCY-VIRUS-INFECTION ; SERIAL-ADDITION TASK ; CEREBRAL VOLUME LOSS ; NEUROPSYCHOLOGICAL IMPAIRMENT ; NEUROCOGNITIVE IMPAIRMENT ; RISK-FACTOR ; AIDS ; DEPRESSION ; FLUENCY ; AGE
英文摘要:

The HIV epidemic in China has been increasing exponentially, yet there have been no studies of the neurobehavioral effects of HIV infection in that country. Most neuroAIDS research has been conducted in Western countries using Western nellropsychological (NP) methods, and it is unclear whether these testing methods are appropriate for use in China. Twenty-eight HIV seropositive (HIV+) and twenty-three HIV seronegative (HIV-) individuals with comparable gender. age. and education distributions were recruited in Beijing and the rural Anhui province in China. Thirty-nine HIV+ and thirty-one HIV- individuals were selected from a larger U.S. cohort recruited at the HIV Neurobehavioral Research Center, in San Diego, to be matched to the Chinese sample for age, disease status, and treatment variables. The NP test battery used with the U.S. and China cohorts included instruments widely used to study HIV infection in the United States. It consisted of 14 individual test measures, each assigned to one of seven ability areas thought to be especially vulnerable to effects of HIV oil the brain (i.e., verbal fluency, abstraction/executive function, speed of information processing, working memory, learning, delayed recall, and motor function). To explore the cross-cultural equivalence and validity of the NP measures, we compared our Chinese and U.S. samples on the individual tests, as well as mean scaled scores for the total battery and seven ability domains. On each NP test measure, the mean of the Chinese HIV+ group was worse than that of the HIV-group. A series of 2 X 2 analyses of variance involving HIV+ and HIV- groups from both countries revealed highly significant HIV effects on the Global and all Domain mean scaled scores. Country effects appeared on two of the individual ability areas, at least partly due to education differences between the two countries. Importantly, the absence of HIV-by-Country interactions suggests that the NP effects of HIV are similar in the two countries. The NP test battery that was chosen and adapted for use in this study of HIV in China appears to have good cross-cultural equivalence, but appropriate Chinese norms will be needed to identify disease-related impairment in individual Chinese people. To inform the development of such norms, a much larger study of demographic effects will be needed. especially considering the wide range of education in that country.

语种: 英语
WOS记录号: WOS:000249140500005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68047
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.VA San Diego Hlth Care Syst, San Diego, CA USA
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
4.Peking Univ, NCAIDS STD Control & Prevent, Beijing 100871, Peoples R China

Recommended Citation:
Cysique, Lucette A.,Jin, Hua,Franklin, Donald R., Jr.,et al. Neurobehavioral effects of HIV-1 infection in china and the united states: A pilot study[J]. JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY,2007,13(5):781-790.
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