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学科主题临床医学
Deficiency of SATB1 expression in Sezary cells causes apoptosis resistance by regulating FasL/CD95L transcription
Wang, Yang1,2; Su, Mingwan1,3; Zhou, Liang L.4; Tu, Ping2; Zhang, Xuejun5; Jiang, Xiaoyan4,6; Zhou, Youwen1,3,5
刊名BLOOD
2011-04-07
DOI10.1182/blood-2010-07-294819
117期:14页:3826-3835
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]PERIPHERAL T-CELLS ; LYMPHOMA-CELLS ; CUTANEOUS-LYMPHOMAS ; ABERRANT EXPRESSION ; TYROSINE KINASE ; BINDING PROTEIN ; GENE-EXPRESSION ; DEATH RECEPTOR ; UP-REGULATION ; FAS-LIGAND
英文摘要

Sezary syndrome (SS) is an aggressive subtype of cutaneous T-cell lymphoma that is characterized by circulating leukemic Sezary cells. The accumulation of these malignant cells has been shown to be the result of the resistance to apoptosis, in particular, activation-induced cell death. However, the mechanism of apoptosis resistance remains unknown. By characterizing the gene transcription profiles of purified CD4(+)CD7(-) Sezary cells from patients with SS and cultured Sezary cells, it was found that Sezary cells are deficient in the expression of special AT-rich region binding protein 1 (SATB1), a key regulator of T-cell development and maturation. Retrovirus-mediated gene transduction revealed that SATB1 restoration in cultured Sezary cells (Hut78) triggered spontaneous cell death and sensitized Hut78 cells to activation-induced cell death, with associated activation of caspase 8 and caspase 3. Furthermore, endogenous expression of FasL in Sezary cells was increased in transcriptional and translational levels on restoration of SATB1 expression in cultured Sezary cells. These results suggest that deficiency in SATB1 expression in Sezary cells plays an important role in SS pathogenesis by causing apoptosis resistance. Thus, restoration of SATB1 expression may represent a potential molecular targeted therapy for SS, which does not have a cure at present. (Blood. 2011;117(14):3826-3835)

语种英语
WOS记录号WOS:000289265500018
项目编号2010-700289 ; 81072233
资助机构Canadian Dermatology Foundation ; Canadian Cancer Society ; Cancer Research Society ; Leukemia &amp ; Lymphoma Society of Canada ; National Nature Science Foundation of China
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68049
专题北京大学第一临床医学院
北京大学第一临床医学院_皮肤性病科
作者单位1.Univ British Columbia, Dept Dermatol & Skin Sci, Vancouver, BC V5Z 4E8, Canada
2.Peking Univ, Dept Dermatol & Venerol, Hosp 1, Beijing 100871, Peoples R China
3.Vancouver Coastal Hlth Res Inst, Mol Med Lab, Chieng Genom Ctr, Vancouver, BC, Canada
4.British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada
5.Anhui Med Univ, Inst Dermatol, Hefei, Peoples R China
6.Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 4E8, Canada
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GB/T 7714
Wang, Yang,Su, Mingwan,Zhou, Liang L.,et al. Deficiency of SATB1 expression in Sezary cells causes apoptosis resistance by regulating FasL/CD95L transcription[J]. BLOOD,2011,117(14):3826-3835.
APA Wang, Yang.,Su, Mingwan.,Zhou, Liang L..,Tu, Ping.,Zhang, Xuejun.,...&Zhou, Youwen.(2011).Deficiency of SATB1 expression in Sezary cells causes apoptosis resistance by regulating FasL/CD95L transcription.BLOOD,117(14),3826-3835.
MLA Wang, Yang,et al."Deficiency of SATB1 expression in Sezary cells causes apoptosis resistance by regulating FasL/CD95L transcription".BLOOD 117.14(2011):3826-3835.
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