IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Subclinical hypothyroidism and its association with lupus nephritis: a case control study in a large cohort of Chinese systemic lupus erythematosus patients
Gao, H.; Li, C.; Mu, R.; Guo, Y-Q; Liu, T.; Chen, S.; Su, Y.; Li, Z-G
关键词lupus nephritis subclinical hypothyroidism systemic lupus erythematosus
刊名LUPUS
2011-10-01
DOI10.1177/0961203311401456
20期:10页:1035-1041
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
资助者Beijing Natural Science Foundation ; Beijing Natural Science Foundation
研究领域[WOS]Rheumatology
关键词[WOS]C-REACTIVE PROTEIN ; AUTOIMMUNE THYROID-DISEASE ; CHRONIC KIDNEY-DISEASE ; CORONARY-HEART-DISEASE ; LOW-GRADE INFLAMMATION ; STAGE RENAL-DISEASE ; CARDIOVASCULAR-DISEASE ; LOW TRIIODOTHYRONINE ; PREVALENCE ; DYSFUNCTION
英文摘要

The aim of this study was to evaluate the prevalence of thyroid diseases in Chinese systemic lupus erythematosus (SLE) patients and the relevance of subclinical hypothyroidism (SCH) with lupus nephritis (LN). A large cohort of 1006 SLE patients was retrospectively analyzed. The prevalence of autoimmune thyroid disease was 2.78%, clinical hypothyroidism 1.69%, subclinical hypothyroidism 10.04%, central hypothyroidism 1.29%, hyperthyroidism 1.19%, euthyroid sick syndrome (ESS) 9.54%, and nodules 1.09%, respectively. Compared with the prevalence of thyroid abnormalities in the general Chinese population (0.91-6.05%), SCH was much higher (10.04%) in this study. In addition, SCH was more frequent in patients with LN (13.4%) than those without LN (7.3%, p = 0.001). Case control study was performed to explore the relative risk factors of SCH. In multiple logistic regression models, 24 h urine protein and estimated glomerular filtration rate (eGFR) were retained as independent correlates of SCH after adjusting for demographic variables, risk factors, and other potential con-founders. The results of the present study suggest that SCH is a common complication in SLE patients, and closely related with LN. Lupus (2011) 20, 1035-1041.

语种英语
所属项目编号7072085
资助者Beijing Natural Science Foundation ; Beijing Natural Science Foundation
WOS记录号WOS:000294839100005
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68051
专题北京大学第二临床医学院
作者单位Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
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GB/T 7714
Gao, H.,Li, C.,Mu, R.,et al. Subclinical hypothyroidism and its association with lupus nephritis: a case control study in a large cohort of Chinese systemic lupus erythematosus patients[J]. LUPUS,2011,20(10):1035-1041.
APA Gao, H..,Li, C..,Mu, R..,Guo, Y-Q.,Liu, T..,...&Li, Z-G.(2011).Subclinical hypothyroidism and its association with lupus nephritis: a case control study in a large cohort of Chinese systemic lupus erythematosus patients.LUPUS,20(10),1035-1041.
MLA Gao, H.,et al."Subclinical hypothyroidism and its association with lupus nephritis: a case control study in a large cohort of Chinese systemic lupus erythematosus patients".LUPUS 20.10(2011):1035-1041.
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