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学科主题: 基础医学
题名:
SALVIANOLIC ACID B PROTECTS FROM PULMONARY MICROCIRCULATION DISTURBANCE INDUCED BY LIPOPOLYSACCHARIDE IN RAT
作者: Lin, Fang1; Liu, Yu-Ying2; Xu, Bo1; Sun, Kai2; Wang, Hao-Yan1; Li, Quan2; Wang, Chuan-She2,3; Fan, Jing-Yu2; Zhang, Shu-Wen4; Han, Jing-Yan2,3
关键词: Acute lung injury ; adhesive molecules ; aquaporin ; permeability ; Salvia miltiorrhiza Bunge
刊名: SHOCK
发表日期: 2013-03-01
DOI: 10.1097/SHK.0b013e318283773e
卷: 39, 期:3, 页:317-325
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Critical Care Medicine ; Hematology ; Surgery ; Peripheral Vascular Disease
研究领域[WOS]: General & Internal Medicine ; Hematology ; Surgery ; Cardiovascular System & Cardiology
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; ACUTE LUNG INJURY ; NEUTROPHIL ACCUMULATION ; ENDOTHELIAL-CELLS ; TNF-ALPHA ; KAPPA-B ; EXPRESSION ; MILTIORRHIZA ; ACTIVATION ; MODEL
英文摘要:

The aim of the present study was to examine the effect and possible mechanism of salvianolic acid B (SalB) on pulmonary microcirculation disturbance induced by lipopolysaccharide ( LPS) in rat. Male Sprague-Dawley rats were subjected to thoracotomy under continuous anesthesia and mechanical ventilation. Albumin leakage from pulmonary capillary and the numbers of leukocytes adherent to the pulmonary capillary wall were determined for 60 min by an upright microscope upon LPS (2 mg . kg(-1) . h(-1)) infusion with or without administration of SalB (5 mg . kg(-1) . h(-1)). Pulmonary tissue wet-to-dry weight ratio, tumor necrosis factor alpha, and interleukin 8 in plasma and bronchoalveolar lavage fluid were measured. In addition, the expressions of E-selectin, intercellular adhesion molecule 1, and myeloperoxidase in pulmonary tissue were assessed by immunohistochemistry. The expressions of aquaporin 1 (AQP-1), AQP-5, metalloproteinase 2 (MMP-2), and MMP-9 were assessed by Western blot assay. Pretreatment with SalB significantly attenuated LPS-induced pulmonary microcirculatory disturbance, including the increase in leukocyte adhesion and albumin leakage. In addition, LPS increased pulmonary tissue wet-to-dry weight ratio and tumor necrosis factor alpha and interleukin 8 levels in plasma and bronchoalveolar lavage fluid enhanced the expression of E-selectin, intercellular adhesion molecule 1, myeloperoxidase, MMP-2, and MMP-9, whereas it decreased the expression of AQP-1 and AQP-5 in pulmonary tissue, all of which were attenuated by SalB pretreatment. Salvianolic acid B pretreatment improves pulmonary microcirculation disturbance and lung injury on LPS exposure. More studies are required to evaluate the potential of SalB as an option for protecting lung from endotoxemia.

语种: 英语
所属项目编号: 2008ZX09401
项目资助者: Production of New Medicine Program of Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000315186100014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68052
Appears in Collections:基础医学院_北大医学部天士力微循环研究中心_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Friendship Hosp, Dept Pulmonol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
4.Capital Med Univ, Beijing Friendship Hosp, Dept Infect, Beijing, Peoples R China

Recommended Citation:
Lin, Fang,Liu, Yu-Ying,Xu, Bo,et al. SALVIANOLIC ACID B PROTECTS FROM PULMONARY MICROCIRCULATION DISTURBANCE INDUCED BY LIPOPOLYSACCHARIDE IN RAT[J]. SHOCK,2013,39(3):317-325.
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