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学科主题: 药学
题名:
The In Vitro and In Vivo Study on Self-Nanoemulsifying Drug Delivery System (SNEDDS) Based on Insulin-Phospholipid Complex
作者: Zhang, Qianyu3; He, Na3; Zhang, Li3; Zhu, Feng3; Chen, Qiuxia3; Qin, Yao3; Zhang, Zhirong3; Zhang, Qiang2; Wang, Shuang1; He, Qin3
关键词: Insulin-Phospholipid Complex (IPC) ; Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) ; MDCK Monolayer ; Diabetic Models ; Enhanced Oral Absorption
刊名: JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
发表日期: 2012-02-01
DOI: 10.1166/jbn.2012.1371
卷: 8, 期:1, 页:90-97
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Medicine, Research & Experimental
研究领域[WOS]: Science & Technology - Other Topics ; Research & Experimental Medicine
关键词[WOS]: INTESTINAL LYMPHATIC TRANSPORT ; ORAL DELIVERY ; PHYSICOCHEMICAL CHARACTERIZATION ; CYCLOSPORINE-A ; ABSORPTION ; NANOPARTICLES ; FORMULATION ; RATS ; PERMEABILITY ; ORIDONIN
英文摘要:

Self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of insulin after oral administration, where insulin was complexed with phospholipid to achieve a better liposolubility in the form of insulin-phospholipid complex (IPC). IPC was formulated into the oil phase of SNEDDS by solvent-evaporation method. The formula of IPC-SNEDDS was optimized and characterized. Data showed that SNEDDS as a drug vehicle did not exhibit an obvious inhibition over MDCK cells, and it can facilitate the transport of IPC across MDCK cell monolayer. IPC-SNEDDS could enhance the absorption of insulin after oral administration and yielded a pronounced hypoglycemic effect on diabetic Wistar rats. All these suggested that IPC-SNEDDS has a great potential for oral delivery of insulin.

语种: 英语
所属项目编号: 2009CB903300 ; 2009SZ0141
项目资助者: National Basic Research Program of China ; Sichuan Province Science and technology support program
WOS记录号: WOS:000302828300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68056
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Sichuan Univ, W China Hosp, Chengdu 610041, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Sichuan Univ, W China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Sichuan, Peoples R China

Recommended Citation:
Zhang, Qianyu,He, Na,Zhang, Li,et al. The In Vitro and In Vivo Study on Self-Nanoemulsifying Drug Delivery System (SNEDDS) Based on Insulin-Phospholipid Complex[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2012,8(1):90-97.
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