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The In Vitro and In Vivo Study on Self-Nanoemulsifying Drug Delivery System (SNEDDS) Based on Insulin-Phospholipid Complex
Zhang, Qianyu3; He, Na3; Zhang, Li3; Zhu, Feng3; Chen, Qiuxia3; Qin, Yao3; Zhang, Zhirong3; Zhang, Qiang2; Wang, Shuang1; He, Qin3
关键词Insulin-Phospholipid Complex (IPC) Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) MDCK Monolayer Diabetic Models Enhanced Oral Absorption
刊名JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
2012-02-01
DOI10.1166/jbn.2012.1371
8期:1页:90-97
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Medicine, Research & Experimental
资助者National Basic Research Program of China ; Sichuan Province Science and technology support program ; National Basic Research Program of China ; Sichuan Province Science and technology support program
研究领域[WOS]Science & Technology - Other Topics ; Research & Experimental Medicine
关键词[WOS]INTESTINAL LYMPHATIC TRANSPORT ; ORAL DELIVERY ; PHYSICOCHEMICAL CHARACTERIZATION ; CYCLOSPORINE-A ; ABSORPTION ; NANOPARTICLES ; FORMULATION ; RATS ; PERMEABILITY ; ORIDONIN
英文摘要

Self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of insulin after oral administration, where insulin was complexed with phospholipid to achieve a better liposolubility in the form of insulin-phospholipid complex (IPC). IPC was formulated into the oil phase of SNEDDS by solvent-evaporation method. The formula of IPC-SNEDDS was optimized and characterized. Data showed that SNEDDS as a drug vehicle did not exhibit an obvious inhibition over MDCK cells, and it can facilitate the transport of IPC across MDCK cell monolayer. IPC-SNEDDS could enhance the absorption of insulin after oral administration and yielded a pronounced hypoglycemic effect on diabetic Wistar rats. All these suggested that IPC-SNEDDS has a great potential for oral delivery of insulin.

语种英语
所属项目编号2009CB903300 ; 2009SZ0141
资助者National Basic Research Program of China ; Sichuan Province Science and technology support program ; National Basic Research Program of China ; Sichuan Province Science and technology support program
WOS记录号WOS:000302828300009
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68056
Collection北京大学药学院
作者单位1.Sichuan Univ, W China Hosp, Chengdu 610041, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Sichuan Univ, W China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Qianyu,He, Na,Zhang, Li,et al. The In Vitro and In Vivo Study on Self-Nanoemulsifying Drug Delivery System (SNEDDS) Based on Insulin-Phospholipid Complex[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2012,8(1):90-97.
APA Zhang, Qianyu.,He, Na.,Zhang, Li.,Zhu, Feng.,Chen, Qiuxia.,...&He, Qin.(2012).The In Vitro and In Vivo Study on Self-Nanoemulsifying Drug Delivery System (SNEDDS) Based on Insulin-Phospholipid Complex.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,8(1),90-97.
MLA Zhang, Qianyu,et al."The In Vitro and In Vivo Study on Self-Nanoemulsifying Drug Delivery System (SNEDDS) Based on Insulin-Phospholipid Complex".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 8.1(2012):90-97.
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