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Selective filtering defect at the axon initial segment in Alzheimer′s disease mouse models
Sun, Xiaqin1; Wu, Yu1; Gu, Mingxue1; Liu, Zhuo1; Ma, Yuanlin2; Li, Jun2; Zhang, Yan1
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2014-09-30
DOI10.1073/pnas.1411837111
111期:39页:14271-14276
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]AMYLOID-BETA ; NEURONAL POLARITY ; IN-VIVO ; PROTEIN ; PRESENILIN-1 ; TRANSPORT ; ANKYRIN(G) ; GENE ; CONTRIBUTES ; MAINTENANCE
英文摘要

Axon pathology has been widely reported in Alzheimer′s disease (AD) patients and AD mouse models. Herein we report that increased miR-342-5p down-regulates the expression of ankyrin G (AnkG), a protein known to play a critical role in establishing selective filtering machinery at the axon initial segment (AIS). Diminished AnkG expression leads to defective AIS filtering in cultured hippocampal neurons from AD mouse models, as monitored by selective exclusion of large macromolecules from the axons. Furthermore, AnkG-deficiency impairs AIS localization of Na-v 1.6 channels and confines NR2B to the somatodendritic compartments. The expression of exogenous AnkG improved the cognitive performance of 12-mo-old APP/PS1 mice; thus, our data suggest that AnkG and impairment of AIS filtering may play important roles in AD pathology.

语种英语
WOS记录号WOS:000342350200061
项目编号91132718 ; 7142085
资助机构National Science Foundation of China ; Beijing Natural Science Foundation
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68058
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Hosp 6, Beijing 100191, Peoples R China
2.Peking Univ, PKU IDG McGovern Inst Brain Res, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
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GB/T 7714
Sun, Xiaqin,Wu, Yu,Gu, Mingxue,et al. Selective filtering defect at the axon initial segment in Alzheimer′s disease mouse models[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014,111(39):14271-14276.
APA Sun, Xiaqin.,Wu, Yu.,Gu, Mingxue.,Liu, Zhuo.,Ma, Yuanlin.,...&Zhang, Yan.(2014).Selective filtering defect at the axon initial segment in Alzheimer′s disease mouse models.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,111(39),14271-14276.
MLA Sun, Xiaqin,et al."Selective filtering defect at the axon initial segment in Alzheimer′s disease mouse models".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111.39(2014):14271-14276.
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