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学科主题: 临床医学
题名:
Single nucleotide polymorphisms of CD20 gene and their relationship with clinical efficacy of R-CHOP in patients with diffuse large B cell lymphoma
作者: Ding, Huirong1; Jin, Xuan2; Ding, Ning3; Fu, Zhiying3; Song, Yuqin3; Zhu, Jun3
刊名: CANCER CELL INTERNATIONAL
发表日期: 2013-06-10
DOI: 10.1186/1475-2867-13-58
卷: 13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ANTI-CD20 MONOCLONAL-ANTIBODY ; NON-HODGKINS-LYMPHOMA ; RITUXIMAB ; MUTATIONS ; THERAPY ; IDEC-C2B8 ; REGIMENS ; RECEPTOR ; TARGET
英文摘要:

Background: R-CHOP has significantly improved survival rates of patients with diffuse large B cell lymphoma (DLBCL) by similar to 20% as compared to CHOP. CD20 antigen, highly expressed on more than 80% of B-cell lymphomas, is the target for rituximab. The goal of our study was to examine polymorphism in the CD20 gene in Chinese DLBCL population and whether CD20 gene polymorphism is associated with clinical response to R-CHOP.

Method: CD20 gene polymorphism was detected in the entire coding regions including 6 exons by polymerase chain reaction (PCR)-sequencing assay in 164 patients with DLBCL. Among them, 129 patients treated with R-CHOP as frontline therapy (R >= 4 cycles) were assessable for the efficacy.

Results: Polymorphisms at three single nucleotides (SNP) were identified in the entire coding regions of the CD20 gene in the 164 patients. One of them, CD20 Exon2 ([216]) was found to be highly correlated with response to R-CHOP. Patients with homozygous C genotype showed a trend toward higher overall response rate than others with CT plus TT genotype (90.6% vs. 79.5%; P = 0.166). A trend toward higher complete remission (CR) rate was observed in patients with homozygous C genotype (67.4%) compared with CT plus TT genotype (47.1%) (P = 0.091).

Conclusion: These results suggest that there are 3 SNPs in CDS of the CD20 gene in Chinese DLBCL population. The CC genotype at Exon2 ([216]) appears to be associated with favourable response to R-CHOP.

语种: 英语
所属项目编号: 30973484
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000320605700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68059
Appears in Collections:北京大学临床肿瘤学院_中心实验室_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Cent Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Hosp 1, Dept Internal Med Oncol, Beijing 100034, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Lymphom, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Ding, Huirong,Jin, Xuan,Ding, Ning,et al. Single nucleotide polymorphisms of CD20 gene and their relationship with clinical efficacy of R-CHOP in patients with diffuse large B cell lymphoma[J]. CANCER CELL INTERNATIONAL,2013,13.
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