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Knockout Mouse Models of Iron Homeostasis
Fleming, Robert E.1,2; Feng, Qi3; Britton, Robert S.4; Cousins, RJ; Bier, DM; Bowman, BA
关键词anemia foxed genes hemochromatosis hepcidin iron transport
刊名ANNUAL REVIEW OF NUTRITION, VOL 31
2011
DOI10.1146/annurev-nutr-072610-145117
31页:117-137
收录类别BSCI ; SCI
文章类型Book Chapter
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]LINKED SIDEROBLASTIC ANEMIA ; TRANSFERRIN RECEPTOR 2 ; ANTIMICROBIAL PEPTIDE HEPCIDIN ; PROTEASE MATRIPTASE-2 TMPRSS6 ; HEREDITARY MICROCYTIC ANEMIA ; REGULATORY PROTEIN-2 ; DEFICIENT MICE ; TARGETED DISRUPTION ; FRIEDREICH ATAXIA ; OXIDATIVE STRESS
英文摘要

Murine models have made valuable contributions to our understanding of iron metabolism. Investigation of mice with inherited forms of anemia has led to the discovery of novel proteins involved in iron homeostasis. A growing number of murine models are being developed to investigate mitochondrial iron metabolism. Mouse strains are available for the major forms of hereditary hemochromatosis. Findings in murine models support the concept that the pathogenesis of nearly all forms of hereditary hemochromatosis involves inappropriately low expression of hepcidin. The availability of mice with foxed iron-related genes allows the study of the in vivo consequences of cell-selective deletion of these genes.

语种英语
WOS记录号WOS:000294692100007
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68062
专题北京大学第一临床医学院_儿科
作者单位1.St Louis Univ, Sch Med, Dept Pediat, St Louis, MO 63104 USA
2.St Louis Univ, Sch Med, Dept Biochem & Mol Biol, St Louis, MO 63104 USA
3.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
4.St Louis Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, St Louis, MO 63110 USA
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GB/T 7714
Fleming, Robert E.,Feng, Qi,Britton, Robert S.,et al. Knockout Mouse Models of Iron Homeostasis[J]. ANNUAL REVIEW OF NUTRITION, VOL 31,2011,31:117-137.
APA Fleming, Robert E.,Feng, Qi,Britton, Robert S.,Cousins, RJ,Bier, DM,&Bowman, BA.(2011).Knockout Mouse Models of Iron Homeostasis.ANNUAL REVIEW OF NUTRITION, VOL 31,31,117-137.
MLA Fleming, Robert E.,et al."Knockout Mouse Models of Iron Homeostasis".ANNUAL REVIEW OF NUTRITION, VOL 31 31(2011):117-137.
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