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学科主题: 基础医学
题名:
Changes in brain content of nociceptin/orphanin FQ and endomorphin 2 in a rat model of neuropathic pain
作者: Sun, RQ; Wang, Y; Zhao, CS; Chang, JK; Han, JS
关键词: nociceptin/orphanin FQ ; endomorphins ; neuropathic pain ; radioimmunoassay
刊名: NEUROSCIENCE LETTERS
发表日期: 2001-09-21
卷: 311, 期:1, 页:13-16
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: ORPHANIN FQ ; PERIAQUEDUCTAL GRAY ; MORPHINE ; ANALGESIA ; ANTINOCICEPTION ; ANTAGONISM ; TOLERANCE
英文摘要:

Orphanin FQ (OFQ) and endomorphins (EM) are newly characterized members of opioid peptide family. OFQ has been shown to antagonize morphine analgesia at supraspinal level, whereas endomorphins are highly selective endogenous ligands for mu receptor, showing analgesic effect at both spinal and supraspinal level. OFQ and EM-2 (EM2) immunoreactivity (ir) was measured by radioimmunoassay in nociception-related brain areas of rats subjected to L5/L6 spinal nerve ligation, using sham operated rats as control. It was found that: (1) the content of EM2-ir of spinal nerve ligated rats showed a significant increase (778%) in periaqueductal gray (PAG), and a significant decrease (43%) in striatum, compared with the control group. (2) a significant increase of the content of OFQ-ir was found in amygdala (+841%) and PAG (+459%), respectively in spinal nerve ligated rats. High pressure liquid chromatography showed that the EM2-ir and OFQ-ir were both heterogeneous with the major part eluting at the position of EM2 and OFQ standard, respectively. These results suggest that spinal nerve ligation induces significant changes in the content of EM2-ir and OFQ-ir in some discrete brain areas, which may play a role in nociceptive modulation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000171206100004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68068
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Beijing Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Phoenix Pharmaceut Inc, Mt View, CA USA

Recommended Citation:
Sun, RQ,Wang, Y,Zhao, CS,et al. Changes in brain content of nociceptin/orphanin FQ and endomorphin 2 in a rat model of neuropathic pain[J]. NEUROSCIENCE LETTERS,2001,311(1):13-16.
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