IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科
学科主题临床医学
Clinical manifestations of Campylobacter jejuni infection in adolescents and adults, and change in antibiotic resistance of the pathogen over the past 16 years
Hou, Feng-Qin; Sun, Xin-Ting; Wang, Gui-Qiang
关键词Campylobacter adolescents adults antibiotics resistance
刊名SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
2012-06-01
DOI10.3109/00365548.2011.652163
44期:6页:439-443
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]ANTIMICROBIAL SUSCEPTIBILITY ; UNITED-STATES ; ENTERITIS ; FEATURES
英文摘要

Background: Campylobacter jejuni infection, traditionally a paediatric illness, is now seen more frequently in adolescents and adults in northern China. Published surveillance reports on C. jejuni infection in these patients are rare. We aimed to characterize (1) the clinical manifestations of this infection in adolescents and adults, and (2) changes in antibiotic resistance of the pathogen. Methods: We retrospectively examined 492 cases of C. jejuni infection in patients aged >= 14 y treated at the Peking University First Hospital, Beijing, China, for the period January 1994 to December 2010. Results: The disease was more common in patients aged 14-24 y and in men (57.9%; p < 0.0001 vs women). The peak incidence was seen between May and October. The infection manifested with acute diarrhoea (<10 bowel movements per day, loose or mucous stool), fever (mostly low grade), and abdominal cramps and pain. Faecal leukocytes and erythrocytes were demonstrated in, respectively, 90.9% and 79.3% of stool specimens, while leukocytes >10 per high-power field were detected in 70.3%. In 1994-1998, 44.5% of C. jejuni strains were resistant to fluoroquinolone, 0% to gentamicin, and 0% to cefuroxime; in 2005-2010, resistance increased significantly to 97.9%, 16.7%, and 93.0%, respectively (p < 0.0001). The resistance to erythromycin did not change significantly (3% vs 6.4%, p = 0.4). Conclusions: Manifestations of C. jejuni infection in adolescent and adult patients are similar to those in children. Over the 16-y study period, resistance of C. jejuni to fluoroquinolones, gentamicin, and cefuroxime significantly increased.

语种英语
WOS记录号WOS:000304522300006
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68071
专题北京大学第一临床医学院_感染疾病科
作者单位Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
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Hou, Feng-Qin,Sun, Xin-Ting,Wang, Gui-Qiang. Clinical manifestations of Campylobacter jejuni infection in adolescents and adults, and change in antibiotic resistance of the pathogen over the past 16 years[J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES,2012,44(6):439-443.
APA Hou, Feng-Qin,Sun, Xin-Ting,&Wang, Gui-Qiang.(2012).Clinical manifestations of Campylobacter jejuni infection in adolescents and adults, and change in antibiotic resistance of the pathogen over the past 16 years.SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES,44(6),439-443.
MLA Hou, Feng-Qin,et al."Clinical manifestations of Campylobacter jejuni infection in adolescents and adults, and change in antibiotic resistance of the pathogen over the past 16 years".SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 44.6(2012):439-443.
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