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学科主题: 临床医学
题名:
Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN
作者: Xie, Feng1,2,3; Su, Ming4,5; Qiu, Wei1,2,3; Zhang, Min6; Guo, Zhongqiang1,2,3; Su, Boxing1,2,3; Liu, Jie1,2,3; Li, Xuesong1,2,3; Zhou, Liqun1,2,3
关键词: kaempferol ; bladder cancer ; apoptosis ; PTEN ; Akt
刊名: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
发表日期: 2013-11-01
DOI: 10.3390/ijms141121215
卷: 14, 期:11, 页:21215-21226
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: LIQUID-CHROMATOGRAPHY ; CARCINOMA-CELLS ; FLAVONOIDS ; PATHWAY ; ACTIVATION ; RESISTANCE ; INVASION ; INACTIVATION ; PHOSPHATASE ; INHIBITION
英文摘要:

Kaempferol (Kae), a natural flavonoid, is widely distributed in fruits and vegetables. Previous studies have identified Kae as a possible cancer preventive and therapeutic agent. We found Kae to exhibit potent antiproliferation and anti-migration effects in human bladder cancer EJ cells. Kaempferol robustly induced apoptosis in EJ cells in a dose-dependent manner, as evidenced by increased cleavage of caspase-3. Furthermore, we found Kae-induced apoptosis in EJ cells to be associated with phosphatase and the tensin homolog deleted on the chromosome 10 (PTEN)/PI3K/Akt pathway. Kae significantly increased PTEN and decreased Akt phosphorylation. Kae-induced apoptosis was partially attenuated in PTEN-knockdown cells. Our findings indicate that Kae could be an alternative medicine for bladder cancer, based on a PTEN activation mechanism.

语种: 英语
所属项目编号: 7122183
项目资助者: Beijing Natural Science Foundation
WOS记录号: WOS:000328624400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68072
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
3.Natl Urol Canc Ctr, Beijing 100034, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll, FuWai Hosp, Sinogerman Lab Mol Med,State Key Lab Cardiovasc D, Beijing 100037, Peoples R China
5.Chinese Acad Med Sci, Peking Union Med Coll, Cardiovasc Inst, Beijing 100037, Peoples R China
6.Shanxi Med Univ, Dept Urol, Hosp 1, Taiyuan 030001, Peoples R China

Recommended Citation:
Xie, Feng,Su, Ming,Qiu, Wei,et al. Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2013,14(11):21215-21226.
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