IR@PKUHSC  > 北京大学第一临床医学院  > 泌尿外科
学科主题临床医学
Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN
Xie, Feng1,2,3; Su, Ming4,5; Qiu, Wei1,2,3; Zhang, Min6; Guo, Zhongqiang1,2,3; Su, Boxing1,2,3; Liu, Jie1,2,3; Li, Xuesong1,2,3; Zhou, Liqun1,2,3
关键词kaempferol bladder cancer apoptosis PTEN Akt
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2013-11-01
DOI10.3390/ijms141121215
14期:11页:21215-21226
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]LIQUID-CHROMATOGRAPHY ; CARCINOMA-CELLS ; FLAVONOIDS ; PATHWAY ; ACTIVATION ; RESISTANCE ; INVASION ; INACTIVATION ; PHOSPHATASE ; INHIBITION
英文摘要

Kaempferol (Kae), a natural flavonoid, is widely distributed in fruits and vegetables. Previous studies have identified Kae as a possible cancer preventive and therapeutic agent. We found Kae to exhibit potent antiproliferation and anti-migration effects in human bladder cancer EJ cells. Kaempferol robustly induced apoptosis in EJ cells in a dose-dependent manner, as evidenced by increased cleavage of caspase-3. Furthermore, we found Kae-induced apoptosis in EJ cells to be associated with phosphatase and the tensin homolog deleted on the chromosome 10 (PTEN)/PI3K/Akt pathway. Kae significantly increased PTEN and decreased Akt phosphorylation. Kae-induced apoptosis was partially attenuated in PTEN-knockdown cells. Our findings indicate that Kae could be an alternative medicine for bladder cancer, based on a PTEN activation mechanism.

语种英语
WOS记录号WOS:000328624400002
项目编号7122183
资助机构Beijing Natural Science Foundation
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68072
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
3.Natl Urol Canc Ctr, Beijing 100034, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll, FuWai Hosp, Sinogerman Lab Mol Med,State Key Lab Cardiovasc D, Beijing 100037, Peoples R China
5.Chinese Acad Med Sci, Peking Union Med Coll, Cardiovasc Inst, Beijing 100037, Peoples R China
6.Shanxi Med Univ, Dept Urol, Hosp 1, Taiyuan 030001, Peoples R China
推荐引用方式
GB/T 7714
Xie, Feng,Su, Ming,Qiu, Wei,et al. Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2013,14(11):21215-21226.
APA Xie, Feng.,Su, Ming.,Qiu, Wei.,Zhang, Min.,Guo, Zhongqiang.,...&Zhou, Liqun.(2013).Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,14(11),21215-21226.
MLA Xie, Feng,et al."Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14.11(2013):21215-21226.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xie, Feng]的文章
[Su, Ming]的文章
[Qiu, Wei]的文章
百度学术
百度学术中相似的文章
[Xie, Feng]的文章
[Su, Ming]的文章
[Qiu, Wei]的文章
必应学术
必应学术中相似的文章
[Xie, Feng]的文章
[Su, Ming]的文章
[Qiu, Wei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。