IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
MiRNA-365 and miRNA-520c-3p respond to risperidone treatment in first-episode schizophrenia after a 1 year remission
Liu Sha1,2; Yuan Yan-bo1,2; Guan Li-li1,2; Wei Hui3,4; Cheng Zhang1,2; Han Xue1,2; Yang Lei1,2; Pu Cheng-cheng1,2; Yang Fu-de5; Lu Zheng6; Deng Hong7; Zhao Jing-ping8; Yu Xin1,2
关键词schizophrenia miRNA risperidone remission
刊名CHINESE MEDICAL JOURNAL
2013-07-20
DOI10.3760/cma.j.issn.0366-6999.20130781
126期:14页:2676-2680
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Key Project of Scientific and Technical Supporting Programs ; Ministry of Science &amp ; Technology of China ; Capital Health Research and Development of Special ; Fundamental Research Funds for the Central Universities ; National Key Project of Scientific and Technical Supporting Programs ; Ministry of Science &amp ; Technology of China ; Capital Health Research and Development of Special ; Fundamental Research Funds for the Central Universities
研究领域[WOS]General & Internal Medicine
关键词[WOS]MICRORNA EXPRESSION ; PREFRONTAL CORTEX ; SERUM MICRORNAS ; BIOMARKERS ; CANCER ; INDIVIDUALS ; RELIABILITY ; BIOGENESIS ; DISORDERS ; DIAGNOSIS
英文摘要

Background MicroRNAs (miRNAs) control gene expression by destabilizing target transcripts and inhibiting their translation. Aberrant expression of miRNAs has been described in many human diseases, including schizophrenia. However, the effects on miRNA expression in response to antipsychotic treatment in peripheral circulation have not been thoroughly examined.

Methods Using quantitative real-time PCR (qRT-PCR), We quantified the expression of seven candidate miRNAs in plasma samples of 40 first-episode schizophrenics before and after antipsychotic treatment. The patients were all treated with risperidone and achieved remission in 1 year.

Results Compared with the baseline, the expression levels of miR-365 and miR-520c-3p were significantly down-regulated after 1 year of risperidone treatment (P <0.001). There were no significant correlations between the clinical symptoms and the expression levels of these two miRNAs (P >0.05).

Conclusions This study analyzed possible circulating miRNAs in response to antipsychotic monotherapy for schizophrenia, the further mechanism need to be confirmed.

语种英语
所属项目编号2007BAI17B04 ; 2009-3030 ; 2012S05
资助者National Key Project of Scientific and Technical Supporting Programs ; Ministry of Science &amp ; Technology of China ; Capital Health Research and Development of Special ; Fundamental Research Funds for the Central Universities ; National Key Project of Scientific and Technical Supporting Programs ; Ministry of Science &amp ; Technology of China ; Capital Health Research and Development of Special ; Fundamental Research Funds for the Central Universities
WOS记录号WOS:000329015300017
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68074
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
3.Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China
4.Chinese Acad Med Sci, Natl Lab Med Mol Biol, Inst Basic Med Sci, Beijing 100005, Peoples R China
5.Peking Union Med Coll, Beijing 100005, Peoples R China
6.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing 100096, Peoples R China
7.Sichuan Univ, Mental Hlth Ctr, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
8.Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China
推荐引用方式
GB/T 7714
Liu Sha,Yuan Yan-bo,Guan Li-li,et al. MiRNA-365 and miRNA-520c-3p respond to risperidone treatment in first-episode schizophrenia after a 1 year remission[J]. CHINESE MEDICAL JOURNAL,2013,126(14):2676-2680.
APA Liu Sha.,Yuan Yan-bo.,Guan Li-li.,Wei Hui.,Cheng Zhang.,...&Yu Xin.(2013).MiRNA-365 and miRNA-520c-3p respond to risperidone treatment in first-episode schizophrenia after a 1 year remission.CHINESE MEDICAL JOURNAL,126(14),2676-2680.
MLA Liu Sha,et al."MiRNA-365 and miRNA-520c-3p respond to risperidone treatment in first-episode schizophrenia after a 1 year remission".CHINESE MEDICAL JOURNAL 126.14(2013):2676-2680.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu Sha]的文章
[Yuan Yan-bo]的文章
[Guan Li-li]的文章
百度学术
百度学术中相似的文章
[Liu Sha]的文章
[Yuan Yan-bo]的文章
[Guan Li-li]的文章
必应学术
必应学术中相似的文章
[Liu Sha]的文章
[Yuan Yan-bo]的文章
[Guan Li-li]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。