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学科主题: 精神卫生
题名:
MiRNA-365 and miRNA-520c-3p respond to risperidone treatment in first-episode schizophrenia after a 1 year remission
作者: Liu Sha1,2; Yuan Yan-bo1,2; Guan Li-li1,2; Wei Hui3,4; Cheng Zhang1,2; Han Xue1,2; Yang Lei1,2; Pu Cheng-cheng1,2; Yang Fu-de5; Lu Zheng6; Deng Hong7; Zhao Jing-ping8; Yu Xin1,2
关键词: schizophrenia ; miRNA ; risperidone ; remission
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-07-20
DOI: 10.3760/cma.j.issn.0366-6999.20130781
卷: 126, 期:14, 页:2676-2680
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: MICRORNA EXPRESSION ; PREFRONTAL CORTEX ; SERUM MICRORNAS ; BIOMARKERS ; CANCER ; INDIVIDUALS ; RELIABILITY ; BIOGENESIS ; DISORDERS ; DIAGNOSIS
英文摘要:

Background MicroRNAs (miRNAs) control gene expression by destabilizing target transcripts and inhibiting their translation. Aberrant expression of miRNAs has been described in many human diseases, including schizophrenia. However, the effects on miRNA expression in response to antipsychotic treatment in peripheral circulation have not been thoroughly examined.

Methods Using quantitative real-time PCR (qRT-PCR), We quantified the expression of seven candidate miRNAs in plasma samples of 40 first-episode schizophrenics before and after antipsychotic treatment. The patients were all treated with risperidone and achieved remission in 1 year.

Results Compared with the baseline, the expression levels of miR-365 and miR-520c-3p were significantly down-regulated after 1 year of risperidone treatment (P <0.001). There were no significant correlations between the clinical symptoms and the expression levels of these two miRNAs (P >0.05).

Conclusions This study analyzed possible circulating miRNAs in response to antipsychotic monotherapy for schizophrenia, the further mechanism need to be confirmed.

语种: 英语
所属项目编号: 2007BAI17B04 ; 2009-3030 ; 2012S05
项目资助者: National Key Project of Scientific and Technical Supporting Programs ; Ministry of Science &amp ; Technology of China ; Capital Health Research and Development of Special ; Fundamental Research Funds for the Central Universities
WOS记录号: WOS:000329015300017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68074
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
3.Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China
4.Chinese Acad Med Sci, Natl Lab Med Mol Biol, Inst Basic Med Sci, Beijing 100005, Peoples R China
5.Peking Union Med Coll, Beijing 100005, Peoples R China
6.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing 100096, Peoples R China
7.Sichuan Univ, Mental Hlth Ctr, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
8.Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China

Recommended Citation:
Liu Sha,Yuan Yan-bo,Guan Li-li,et al. MiRNA-365 and miRNA-520c-3p respond to risperidone treatment in first-episode schizophrenia after a 1 year remission[J]. CHINESE MEDICAL JOURNAL,2013,126(14):2676-2680.
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