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学科主题: 临床医学
题名:
Early Systolic Blood Pressure Changes in Incident Hemodialysis Patients Are Associated with Mortality in the First Year
作者: Sipahioglu, Murat H.1,2; Usvyat, Len2; Liu, Li2,4; Abbas, Samer R.2; Raimann, Jochen G.2; Rosales, Laura2; Levin, Nathan W.2; Kotanko, Peter2,3
关键词: Hemodialysis ; Mortality ; Systolic blood pressure
刊名: KIDNEY & BLOOD PRESSURE RESEARCH
发表日期: 2012
DOI: 10.1159/000342634
卷: 35, 期:6, 页:663-670
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Physiology ; Urology & Nephrology ; Peripheral Vascular Disease
研究领域[WOS]: Physiology ; Urology & Nephrology ; Cardiovascular System & Cardiology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; UNITED-STATES ; SURVIVAL ; DIALYSIS ; OUTCOMES ; RISK ; RACE
英文摘要:

Background: In incident hemodialysis (HD) patients, the relationship between early systolic blood pressure (SBP) dynamics and mortality is unknown. Methods: Baseline SBP levels were stratified into 5 categories ranging from <120 and >= 180 mm Hg. Early pre-HD SBP change was defined as the slope of pre-HD SBP from week 1 to 12 and categorized in quartiles (Q1, lowest slope). SBP slopes were computed for each patient by simple linear regression. Results: In 3,446 incident HD patients (42% females, 44% black, age 62 +/- 15 years), the median pre-HD SBP slope was -1.7 (Q1) to +2.3 (Q4) mm Hg/week. In an adjusted multivariate Cox regression analysis, patients with declining SBP (slope Q1) had higher mortality compared to patients with increasing pre-HD SBP (slope Q4) at 12 months (hazard ratio 2.01, 95% confidence interval 1.35-3.01). In addition, patients with baseline pre-HD SBP <120 mm Hg showed higher mortality compared to the reference group (SBP >= 180 mm Hg) at 12 months (hazard ratio 1.89, 95% confidence interval 1.03-3.45). Conclusion: Baseline pre-HD SBP and early SBP dynamics are associated with mortality in the first year of dialysis. Patients who had low (pre-HD SBP <120 mm Hg) or declining SBP had the highest mortality rates. Particular attention is warranted in incident HD patients with low or declining SBP. Copyright (C) 2012 S. Karger AG, Basel

语种: 英语
WOS记录号: WOS:000314461100035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68075
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Renal Res Inst, New York, NY 10128 USA
2.Beth Israel Deaconess Med Ctr, New York, NY 10003 USA
3.Erciyes Univ, Dept Nephrol, Fac Med, Kayseri, Turkey
4.Peking Univ, Hosp 1, Inst & Div Nephrol, Beijing 100871, Peoples R China

Recommended Citation:
Sipahioglu, Murat H.,Usvyat, Len,Liu, Li,et al. Early Systolic Blood Pressure Changes in Incident Hemodialysis Patients Are Associated with Mortality in the First Year[J]. KIDNEY &amp; BLOOD PRESSURE RESEARCH,2012,35(6):663-670.
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